Type I interferon is considered to be a key cytokine in influenza virus-induced acute lung injury (ALI), in which IRF3 and IRF7 play particularly important roles. However, whether all nine members of IRF family are involved in influenza virus-induced immune response is currently unknown. In this study, we found that all members of IRF family responded to influenza virus. The IRF family expression profile seems to be related to the pathogenicity of the particular influenza virus strain. The influenza virus mainly relies on endosomal TLR signals and the positive feedback loop of IFN-I to cause either direct or indirect different expression of all IRF family members locally or systemically. Interestingly, IRF6 was somewhat different from other IRF family members during influenza virus infection. Overall, the expression profile of the IRF family may be a valuable reference for the prevention and treatment of influenza complications, which encourage further, more in-depth research.

I型干扰素被认为是流感病毒引起的急性肺损伤（ALI）的关键细胞因子，其中IRF3和IRF7发挥特别重要的作用。然而，目前尚不清楚IRF家族的所有九个成员是否都参与了流感病毒诱导的免疫反应。在这项研究中，我们发现IRF家族的所有成员都对流感病毒有反应。IRF家族表达谱似乎与特定流感病毒株的致病性有关。流感病毒主要依靠内体TLR信号和IFN-I的正反馈回路来引起局部或全身性IRF家族成员的直接或间接不同表达。有趣的是，在流感病毒感染期间，IRF6与其他IRF家族成员有所不同。总体，