Highlights • Observational studies of the role of inflammation on self-harm have conflicting results.• We used Mendelian Randomisation, a novel causal inference technique to explore this.• Genetic liability for high levels of IL-6 were not associated with self-harm.• We found some evidence that higher levels of CRP were protective for self-harm.• This potential protective effect of CRP has also been found for schizophrenia.

中文翻译：

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调查炎症与自残之间因果关系的证据：多变量孟德尔随机化研究


亮点 • 关于炎症对自残作用的观察性研究得出了相互矛盾的结果。• 我们使用孟德尔随机化（一种新型因果推理技术）来探索这一点。• 高水平 IL-6 的遗传倾向与自残无关。 • 我们发现一些证据表明，较高水平的CRP 对自残有保护作用。 • CRP 的这种潜在保护作用也被发现对精神分裂症有保护作用。