Tacrine (Amino tetrahydroacridine hydrochloride hydrate) is a non-competitive and reversible inhibitor of acetylcholine esterase, and butylcholinesterase. Alzheimer’s disease (AD) shows multiple types of pathological pathway in which cholinergic neuron deficiency is 95 % popular and the oldest pathological mechanism. However, the effect of tacrine on the hippocampal dependent memory is not yet known. In this study, we did verify that tacrine induced recovery of the specific pattern associated memory along with long-term memory through the improvement in the pattern of neural oscillation from deficits condition in the hippocampus of 6th month old AD mice. Our results showed that tacrine improved the performance of Morris water maze related spatial cognitive functions, and enhanced LTP in AD-TAC mice. Furthermore, our results implied that tacrine strongly improve the patterns of neural oscillations, and hippocampal synaptic plasticity in the 6th month old APP-PS1 double transgenic AD-TAC mice via changing the theta and alpha power spectra including with the improvement in theta, alpha and gamma synchronization. Moreover, tacrine generated the improvement in the theta cross spectra, theta-gamma phase-phase synchronization and theta-gamma phase-amplitude coupling. Besides, the data represented that tacrine accelerated the expression of NR2B, SYP and GAD65 while it caused deceleration on the expression of GAD67 neurotransmitter and Aβ. Thus, our results infer that tacrine works as a strong causative agent for improving the specific pattern-associated spatial long-term memory in the AD mice without showing any side effect.

他克林（氨基四氢吖啶盐酸盐水合物）是乙酰胆碱酯酶和丁基胆碱酯酶的非竞争性和可逆抑制剂。阿尔茨海默病 (AD) 表现出多种类型的病理途径，其中胆碱能神经元缺乏症占 95%，并且是最古老的病理机制。然而，他克林对海马依赖性记忆的影响尚不清楚。在这项研究中，我们确实通过改善 6 个月大 AD 小鼠海马体缺陷状况的神经振荡模式，证实了他克林诱导特定模式相关记忆和长期记忆的恢复。我们的结果表明，他克林改善了莫里斯水迷宫相关空间认知功能的表现，并增强了 AD-TAC 小鼠的 LTP。此外，我们的结果表明，他克林通过改变 theta 和 alpha 功率谱，包括改善 theta、alpha 和 gamma 同步，显着改善了 6 个月大的 APP-PS1 双转基因 AD-TAC 小鼠的神经振荡模式和海马突触可塑性. 此外，他克林在 theta 交叉光谱、theta-gamma 相位-相位同步和 theta-gamma 相位-幅度耦合方面产生了改进。此外，数据表明他克林加速了NR2B、SYP和GAD65的表达，而导致GAD67神经递质和Aβ的表达减速。因此，我们的结果推断，他克林是一种强有力的病原体，可以改善 AD 小鼠中特定模式相关的空间长期记忆，而没有任何副作用。