Dopamine (DA) in medial prefrontal cortex is crucial in extinction of aversive or appetitive experiences. Although attention has been mostly focused on the infralimbic area of prefrontal cortex, a role of the prelimbic (PL) area has been envisaged pointing to DA transmission in the extinction of drug conditioned behavior. Evidence shows that DA exerts its action also via both D1 and D2 receptor subtypes.

Here we investigated the effects of D1 and D2 receptor agonist microinfusion in the PL cortex of C57BL/6J mice on expression and extinction of amphetamine-induced conditioned place preference (CPP), in order to ascertain the effects of selective vs concomitant receptor subtypes stimulation.

SKF38393 and Quinpirole were used at doses not impairing expression of amphetamine-induced CPP on the day of infusion. Acute infusion of each agonist alone did not affect extinction in subsequent days in comparison with Vehicle-treated mice, while concomitant infusion of both agonists produced a clear-cut advance of extinction of preference for the compartment previously paired with amphetamine.

These results show that concomitant stimulation of D1 and D2 receptors in PL is required to foster extinction suggesting a synergic action between receptors or a heteromeric receptor involvement.

内侧前额叶皮层中的多巴胺（DA）对于消除厌恶或食欲体验至关重要。尽管注意力主要集中在前额叶皮层的下边缘区域，但已经设想前边缘 (PL) 区域的作用指向 DA 传输在药物条件行为的灭绝中。证据表明，DA 还通过 D1 和 D2 受体亚型发挥作用。

在这里，我们研究了 C57BL/6J 小鼠 PL 皮层中 D1 和 D2 受体激动剂微量输注对苯丙胺诱导的条件性位置偏好 (CPP) 表达和消失的影响，以确定选择性与伴随受体亚型刺激的影响。

SKF38393 和喹吡罗在输注当天以不损害苯丙胺诱导的 CPP 表达的剂量使用。与载体处理的小鼠相比，单独急性输注每种激动剂不会影响随后几天的消退，而同时输注两种激动剂对先前与安非他明配对的隔室产生了明显的偏好消退。

这些结果表明，需要同时刺激 PL 中的 D1 和 D2 受体以促进灭绝，这表明受体之间的协同作用或异聚受体的参与。