Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides,Organic Chemistry Frontiers

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Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-05-28 , DOI: 10.1039/d0qo00367k
Shiwen Liu _{1,

2,

3,

4,

5} , Xiaojun Zeng _{6,

7,

8,

9,

10} , Bo Xu _{6,

7,

8,

9,

10}

Affiliation

We have developed a highly regioselective halothiolation of alkynes under simple and mild conditions. Our halothiolation reagents are readily available alkali metal halides and N-thiosuccinimides. Our transition metal-free system offers good chemical yields for a wide range of alkyne substrates with satisfactory regioselectivity and good functional group tolerance.

中文翻译：

使用卤化锂和N-硫代琥珀酰亚胺对炔烃进行区域和立体选择性卤代硫醇化

我们已经开发出了在简单温和条件下炔烃的高度区域选择性卤代硫醇化反应。我们的卤代硫代试剂是易于获得的碱金属卤化物和N-硫代琥珀酰亚胺。我们的无过渡金属系统可为各种炔烃底物提供良好的化学收率，并具有良好的区域选择性和良好的官能团耐受性。

更新日期：2020-06-30

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