The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles.,Nano Letters

当前位置： X-MOL 学术 › Nano Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles.
Nano Letters ( IF 9.6 ) Pub Date : 2020-05-28 , DOI: 10.1021/acs.nanolett.0c01196
Le Wang _{1,

2} , Sixiang Li ₂ , Jiaxiang Yin ₃ , Junchuan Yang ₃ , Qizhen Li ₂ , Wenfu Zheng ₃ , Shaoqin Liu ₁ , Xingyu Jiang _{1,

2}

Affiliation

With the widespread use of antibiotics, the number of complex infection cases caused by unknown pathogens is increasing and novel antibiotics with tunable antibacterial spectra and low toxicity are highly desirable. Herein, we report that, by selecting thiol or amine, two groups with different binding affinities with gold, as anchoring groups, phenylboronic acid can be decorated on gold nanoparticles (AuNPs) with different densities, which contributes to Gram-selective antibacterial activities of the AuNPs. The AuNPs modified with amine- or thiol-tethered phenylboronic acids specifically bind to lipopolysaccharide (LPS, Gram-negative) or lipoteichoic acid (LTA, Gram-positive), respectively. By modifying AuNPs with different ratios of thiol- and amine-tethered phenylboronic acids, the resulting AuNPs show potent and tunable antibacterial activity. The AuNP-based antibacterial agents with optional Gram selectivity are promising for applications in personalized therapy.

中文翻译：

表面涂层的密度可有助于金纳米颗粒的不同抗菌活性。

随着抗生素的广泛使用，由未知病原体引起的复杂感染病例的数量正在增加，并且非常需要具有可调的抗菌谱和低毒性的新型抗生素。在本文中，我们报道，通过选择硫醇或胺，将与金具有不同结合亲和力的两个基团作为锚定基团，可以在密度不同的金纳米颗粒（AuNPs）上修饰苯基硼酸，这有助于该化合物的革兰氏选择性抗菌活性。 AuNPs。用胺或硫醇系苯基硼酸修饰的AuNPs分别与脂多糖（LPS，革兰氏阴性）或脂蛋白酸（LTA，革兰氏阳性）特异性结合。通过用不同比例的巯基和胺基连接的苯基硼酸修饰AuNP，所得的AuNP显示出有效且可调节的抗菌活性。

更新日期：2020-07-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11