Hybridization of resin modified- glass ionomer cement (RMGIC) and bioactive glass (BAG) may result higher mechanical strength and resistance to disintegration, while less contain of polyacrylic acid would lead to bioactivity of the cement. In the present study we investigated the effect of BAG from the CaSiO 3 -Ca 3 (PO 4 ) 2 system addition to the bioactivity of RMGIC. The BAG containing 10, 15, and 20% of P 2 O 5 (denoted as CSP10, 15, and 20) were used in the study to modify the powder of RMGIC, with apatite wollastonite (AWG) was chosen for a comparison. The surface bioactivity was assessed using XRD, FT-IR, and SEM analysis after specimen immersion in the simulated body fluid (SBF). Measurement of Ca, P, F, Sr, and Al was conducted for the remaining SBF. Cells studies were done to evaluate cell attachment, proliferation, and differentiation on the RMGIC containing BAG compared to the one without BAG. Results of Sr and Al analysis lead to the conclusion that addition of BAG may not influence stability of the matrix of the cement. It was also confirmed that addition of bioactive glass was positive factor indicating excellent ions exchange in SBF and spontaneous growth of apatite by consuming the Ca and P ions in the surrounding fluid. The ability of osteoblasts differentiation on the four types of bioactive cements were higher than that of RMGIC without BAG. These results might provide novel insights into the development of a new generation of osteoconductive biomedical materials.

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新开发的含有生物活性玻璃的树脂改性玻璃离聚物水泥的骨传导材料

树脂改性的玻璃离聚物水泥（RMGIC）和生物活性玻璃（BAG）的杂交可能会产生更高的机械强度和抗崩解性，而聚丙烯酸的含量较少会导致水泥的生物活性。在本研究中，我们研究了CaSiO 3 -Ca 3（PO 4）2系统中BAG对RMGIC的生物活性的影响。在研究中，使用含有10％，15％和20％P 2 O 5的BAG（分别表示为CSP10、15和20）来改性RMGIC粉末，并选择磷灰石硅灰石（AWG）进行比较。将样品浸入模拟体液（SBF）中后，使用XRD，FT-IR和SEM分析评估表面生物活性。对剩余的SBF进行Ca，P，F，Sr和Al的测量。进行了细胞研究以评估细胞附着，增殖，与不含BAG的RAGIC相比，含RAGIC的BAG的差异更大。Sr和Al分析的结果得出结论，BAG的添加可能不会影响水泥基体的稳定性。还证实了生物活性玻璃的添加是积极的因素，表明通过消耗周围流体中的Ca和P离子，SBF中的离子交换极好，磷灰石自发生长。在四种类型的生物活性胶结剂上，成骨细胞的分化能力均高于没有BAG的RMGIC。这些结果可能为新一代骨传导生物医学材料的开发提供新颖的见解。还证实了生物活性玻璃的添加是积极的因素，表明通过消耗周围流体中的Ca和P离子，SBF中的离子交换极好，磷灰石自发生长。在四种类型的生物活性胶结剂上，成骨细胞的分化能力均高于没有BAG的RMGIC。这些结果可能为新一代骨传导生物医学材料的开发提供新颖的见解。还证实了生物活性玻璃的添加是积极的因素，表明通过消耗周围流体中的Ca和P离子，SBF中的离子交换极好，磷灰石自发生长。在四种类型的生物活性胶结剂上，成骨细胞的分化能力均高于没有BAG的RMGIC。这些结果可能为新一代骨传导生物医学材料的开发提供新颖的见解。