Superb reliability and biocompatibility equip aggregation-induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, we designed a kind of PEGylated AIE (OTPA-BBT) dots with strong absorption and extremely high NIR-II PLQY as 13.6%, and proposed the long-aliphatic-chain design blueprint contributing to their excretion from animal body. Assisted by the OTPA-BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR-IIb), large-depth cerebral vasculature (beyond 600 μm) as well as real-time blood flowing were monitored through-thinned-skull, and noninvasive NIR-IIb imaging with rich high-spatial-frequency information gave a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA-BBT dots from the body was demonstrated, which showed an influential evidence of bio-safety.

中文翻译：

---

生物可排泄的AIE点可在mar猴体内可视化：未来临床纳米医学的视野

出色的可靠性和生物相容性使聚集诱导发射（AIE）点具有巨大的荧光生物成像潜力。但是，仍然长期缺乏可排泄的明亮AIE发射器的设计说明。在这里，我们设计了一种吸收性强，NIR-II PLQY极高的聚乙二醇化AIE（OTPA-BBT）点，其比例为13.6％，并提出了有助于其从动物体内排泄的长脂链设计蓝图。通过OTPA-BBT点具有超过1100 nm甚至1500 nm（NIR-IIb）的明亮荧光，可以通过薄头骨监测大深度脑血管（超过600μm）以及实时血液流动，并具有丰富的高空间频率信息的无创NIR-IIb成像可准确显示mar猴的胃肠道。重要的，