Effects of transcranial direct current stimulation on cortex modulation by stimulation of the primary motor cortex and parietal cortex in humans,International Journal of Neuroscience

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Effects of transcranial direct current stimulation on cortex modulation by stimulation of the primary motor cortex and parietal cortex in humans
International Journal of Neuroscience ( IF 1.7 ) Pub Date : 2020-06-07 , DOI: 10.1080/00207454.2020.1775594
Shahid Bashir ₁ , Dowihi Aisha ₁ , Ali Hamza ₂ , Fawaz Al-Hussain ₃ , Woo-Kyoung Yoo _{4,

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Affiliation

Abstract

Aim of the study

Transcranial magnetic stimulation (TMS) is used to measure corticospinal excitability (CSE) from the primary motor cortex (M1) in humans through motor-evoked potentials (MEPs). The variability of CSE responses to transcranial direct current stimulation (tDCS) protocols is high and needs to be reproduced in the healthy population. The M1 and posterior parietal cortex (PPC) are anatomically and functionally connected and could play a role in understanding the variability in CSE responses. We tested the individual MEPs following a common cathodal (ctDCS) protocol over the M1 and PPC.

Materials and methods

Twenty-eight healthy subjects were randomized for a ctDCS stimulation over the left M1 and PPC for 20 min on a separate days. The first dorsal interosseous muscle (FDI) contralateral stimulation of the left M1 was used as the resting motor threshold (RMT), while 15 single pulses 4–8 s apart at an intensity of 120% RMT were used to determine the baseline MEP amplitude and at T0, 5, 10, 20, 30, 40, 50, and 60 min after ctDCS stimulation in both sessions.

Results

A 20 min duration of ctDCS stimulation significantly deceased the CSE only at T0 (p = 0.046 at M1, p = 0.010 at PPC).

Conclusion

Our results suggested that PPC stimulation can modulate M1 excitability and PPC–M1 connectivity, but a significant effect is only observed immediately post ctDCS. The tDCS showed variability in response to the tDCS protocol is consistent with other non-invasive brain stimulation studies.

中文翻译：

经颅直流电刺激通过刺激人类初级运动皮层和顶叶皮层对皮层调节的影响

摘要

研究目的

经颅磁刺激 (TMS) 用于通过运动诱发电位 (MEP) 测量人类初级运动皮层 (M1) 的皮质脊髓兴奋性 (CSE)。CSE 对经颅直流电刺激 (tDCS) 协议的反应的可变性很高，需要在健康人群中重现。M1 和后顶叶皮层 (PPC) 在解剖学和功能上是相连的，可以在理解 CSE 反应的变异性方面发挥作用。我们在 M1 和 PPC 上按照通用阴极 (ctDCS) 协议测试了各个 MEP。

材料和方法

28 名健康受试者被随机分配，分别在左侧 M1 和 PPC 上进行 20 分钟的 ctDCS 刺激。左侧 M1 的第一个背侧骨间肌 (FDI) 对侧刺激用作静息运动阈值 (RMT)，而以 120% RMT 的强度间隔 4-8 秒的 15 个单脉冲用于确定基线 MEP 幅度和在两个会话中 ctDCS 刺激后的 T0、5、10、20、30、40、50 和 60 分钟。