Thermal and Reactive Oxygen Species Dual-Responsive OEGylated Polysulfides with Oxidation-Tunable Lower Critical Solution Temperatures.,Macromolecular Rapid Communications

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Thermal and Reactive Oxygen Species Dual-Responsive OEGylated Polysulfides with Oxidation-Tunable Lower Critical Solution Temperatures.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-05-27 , DOI: 10.1002/marc.202000206
Runhai Chen _{1,

2} , Zehong Xiang _{1,

3} , Yu Xia _{1,

3} , Zhifang Ma ₁ , Qiang Shi ₁ , Shing-Chung Wong ₄ , Jinghua Yin ₁

Affiliation

In this work, two monomethoxy oligo(ethylene glycol) (OEG)‐substituted episulfides are prepared and a series of polysulfides are synthesized with subsequent ring‐opening polymerization. The OEGylated polysulfides exhibit thermal and reactive oxygen species (ROS) dual‐responsive behavior. Their lower critical solution temperatures (LCSTs) are close to human body temperature and depend on the degree of polymerization and OEG length. Notably, the LCST of the polysulfide increases linearly with the oxidation degree by H₂O₂, showing a highly tunable change regulated by the ratio between hydrophobic sulfide and hydrophilic sulfoxide/sulfone in the backbone. Further, the OEGylated polysulfide can act as a ROS scavenger to protect red blood cells (RBCs) from oxidative damage in an RBCs aging model in vitro. This work paves a facile way to synthesize LCST‐tunable polysulfides, which hold great promise in biological applications.

中文翻译：

热和活性氧物种双反应性OEG酰化多硫化物，具有可氧化调节的较低临界溶液温度。

在这项工作中，制备了两个单甲氧基低聚乙二醇（OEG）取代的环硫醚，并在随后的开环聚合反应中合成了一系列多硫醚。OEG酰化的多硫化物表现出热和活性氧（ROS）双重响应行为。它们的较低临界溶液温度（LCST）接近人体温度，并取决于聚合度和OEG长度。值得注意的是，多硫化物的LCST随H ₂ O ₂的氧化度而线性增加。表现出高度可调的变化，该变化受骨架中疏水性硫化物与亲水性亚砜/砜之比的调节。此外，OEG酰化的多硫化物可以充当ROS清除剂，以保护RBC老化模型中的红细胞（RBC）免受氧化损伤。这项工作为合成LCST可调多硫化物提供了一种简便的方法，这在生物学应用中具有广阔的前景。

更新日期：2020-07-13

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