Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.,Liver International

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Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.
Liver International ( IF 6.0 ) Pub Date : 2020-05-27 , DOI: 10.1111/liv.14542
Svenja Sydor _{1,

2} , Paul Manka ₃ , Lea van Buren ₃ , Sarah Theurer ₄ , Suzan Schwertheim ₄ , Jan Best ₁ , Janette Heegsma _{5,

6} , Ali Saeed _{5,

6} , Diana Vetter ₇ , Martin Schlattjan ₄ , Anna Dittrich ₈ , Maria I Fiel ₉ , Hideo A Baba ₄ , Alexander Dechêne ₁₀ , Francisco J Cubero _{11,

12} , Guido Gerken ₃ , Ali Canbay ₂ , Han Moshage _{5,

6} , Scott L Friedman ₈ , Klaas Nico Faber _{5,

6} , Lars P Bechmann _{1,

2}

Affiliation

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Hospital Magdeburg, Magdeburg, Germany.
Department of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.
Department of Pathology, University Hospital of Essen, Essen, Germany.
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Surgery, University Hospital Zurich, Zurich, Switzerland.
Department of Systems Biology, Institute of Biology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nürnberg Hospital, Department of Internal Medicine 6, Nürnberg, Germany.
Department of Immunology, Opthalmology and ORL, Complutense University School of Medicine, Madrid, Spain.
de Octubre Health Research Institute (imas 12), Madrid, Spain.

Primary sclerosing cholangitis (PSC) is characterized by chronic cholestasis and inflammation, which promotes cirrhosis and an increased risk of cholangiocellular carcinoma (CCA). The transcription factor Krueppel‐like‐factor‐6 (KLF6) is a mediator of liver regeneration, steatosis, and hepatocellular carcinoma (HCC), but no data are yet available on its potential role in cholestasis. Here, we aimed to identify the impact of hepatic KLF6 expression on cholestatic liver injury and PSC and identify potential effects on farnesoid‐X‐receptor (FXR) signalling.

中文翻译：

肝细胞 KLF6 表达影响 FXR 信号传导和原发性硬化性胆管炎的临床过程。

原发性硬化性胆管炎 (PSC) 的特征是慢性胆汁淤积和炎症，这会促进肝硬化和胆管细胞癌 (CCA) 的风险增加。转录因子 Krueppel 样因子 6 (KLF6) 是肝再生、脂肪变性和肝细胞癌 (HCC) 的介质，但尚无关于其在胆汁淤积中的潜在作用的数据。在这里，我们旨在确定肝脏 KLF6 表达对胆汁淤积性肝损伤和 PSC 的影响，并确定对法尼醇-X 受体 (FXR) 信号传导的潜在影响。

更新日期：2020-05-27

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