Electrochemical Amide Bond Formation from Benzaldehydes and Amines: Oxidation by Cathodic‐Generated Hydrogen Peroxide,European Journal of Organic Chemistry

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Electrochemical Amide Bond Formation from Benzaldehydes and Amines: Oxidation by Cathodic‐Generated Hydrogen Peroxide
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-05-27 , DOI: 10.1002/ejoc.202000479
Yuma Kurose ₁ , Yasushi Imada ₁ , Yohei Okada ₂ , Kazuhiro Chiba ₁

Affiliation

The amide bond formation with benzaldehydes and amines by paired electrolysis is reported. 19 amide products were synthesized by this reaction. ¹H NMR studies revealed that the corresponding hemiaminal intermediate is formed, which is then converted into the amide product. Control experiments showed that this electrochemical amidation occurs by anodic oxidation and cathodic generated H₂O₂.