The low dose of radiation (LDR) has received growing attention for its beneficial neuroprotective effect. This study was designed to investigate the enhancing effect of LDR on the antidepressant potential of resveratrol against diazepam‐induced depression in mice. Female mice divided into five groups; control, diazepam (2 mg/kg), LDR (0.5Gy) + diazepam, resveratrol (20 mg/kg) + diazepam, LDR + resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro‐histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.

中文翻译：

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低剂量γ辐射增强白藜芦醇的抗抑郁作用：行为和神经化学研究

低剂量辐射 (LDR) 因其有益的神经保护作用而受到越来越多的关注。本研究旨在研究 LDR 对白藜芦醇对地西泮诱导的小鼠抑郁症的抗抑郁潜力的增强作用。雌性小鼠分为五组；对照，地西泮 (2 mg/kg)、LDR (0.5Gy) + 地西泮、白藜芦醇 (20 mg/kg) + 地西泮、LDR + 白藜芦醇 + 地西泮。接受地西泮的小鼠表现出抑郁症状，表现为在开放场地中运动活动减少，在强迫游泳和悬尾试验中不动时间增加，以及脑组织中生物胺（血清素、去甲肾上腺素和多巴胺）的显着下降。这些作用通过 LDR 或白藜芦醇给药得到改善，显示出抗抑郁活性。有趣的是，LDR 触发了白藜芦醇的抗抑郁作用，因为它恢复了行为测试、神经递质和神经组织结构的变化。总之，这些发现表明 LDR 可以被视为一种新型佐剂，可以增强白藜芦醇的抗抑郁作用，并可能作为一种潜在的抑郁症治疗方法。