Ocular tissues possess a robust antioxidant defence system to minimize oxidative stress and preserve tissue structure and function. Glutathione (GSH) is a powerful antioxidant and in the lens exists at unusually high concentrations. However, with advancing age, GSH levels deplete specifically in the lens centre initiating a chain of biochemical events that ultimately result in protein aggregation, light scattering and age‐related nuclear cataract. However, antioxidant supplementation has been shown to be ineffective in preventing or delaying cataract indicating that a better understanding of the delivery, uptake and metabolism of GSH in the different regions of the lens is required. This information is essential for the development of scientifically informed approaches that target the delivery of GSH to the lens nucleus, the region of the lens most affected by age‐related cataract.

中文翻译：

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晶状体中谷胱甘肽代谢途径的年龄依赖性变化：预防白内障形成的治疗策略的新见解-综述。

眼部组织拥有强大的抗氧化防御系统，可以最大限度地减少氧化应激并保护组织结构和功能。谷胱甘肽 (GSH) 是一种强大的抗氧化剂，并且以异常高的浓度存在于晶状体中。然而，随着年龄的增长，晶状体中心的 GSH 水平会逐渐耗尽，引发一系列生化事件，最终导致蛋白质聚集、光散射和与年龄相关的核白内障。然而，已证明补充抗氧化剂在预防或延缓白内障方面无效，这表明需要更好地了解晶状体不同区域中 GSH 的传递、吸收和代谢。这些信息对于开发以 GSH 递送至晶状体核为目标的科学方法至关重要，