Zn‐MOF‐74 as pH‐Responsive Drug‐Delivery System of Arsenic Trioxide,ChemNanoMat

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Zn‐MOF‐74 as pH‐Responsive Drug‐Delivery System of Arsenic Trioxide
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-06-16 , DOI: 10.1002/cnma.202000221
Jennifer Schnabel ₁ , Romy Ettlinger ₁ , Hana Bunzen ₁

Affiliation

Although arsenic and its compounds are mainly known as a poison, they also found applications as drugs in medicine. However, their distribution in a therapeutic dose is often problematic due to their high toxicity. One possibility how to address this issue is utilizing drug‐delivery systems. Herein, we report on a metal‐organic framework (MOF) called Zn‐MOF‐74, which comprises Zn(II) ions and 2,5‐dihydroxybenzene‐1,4‐dicarboxylate ligands, as a drug nanocarrier of arsenic trioxide. We synthetized the material in a nanoparticle formulation and showed that due to the open metal sites in Zn‐MOF‐74, it was possible to load the material with a high amount of the As(III)‐drug (in a form of arsenous acid). Moreover, we also investigated the drug release at different pH values. Noticeably, we observed that the As(III)‐release was pH‐triggered and was faster at pH 6.0 than at pH 7.4. Therefore, we suggest Zn‐MOF‐74 as a model example of a MOF containing open metal sites for controlled drug loading and delivery.

中文翻译：

Zn-MOF-74作为三氧化二砷的pH响应药物递送系统

尽管砷及其化合物主要被称为毒药，但它们也被发现在医学中用作药物。然而，由于它们的高毒性，它们在治疗剂量中的分布通常是有问题的。解决此问题的一种可能性是利用药物输送系统。在本文中，我们报道了一种称为Zn-MOF-74的金属有机骨架（MOF），它包含Zn（II）离子和2,5-二羟基苯-1,4-二羧酸酯配体，作为三氧化二砷的药物纳米载体。我们以纳米颗粒配方合成了该材料，结果表明，由于Zn-MOF-74中存在开放的金属位点，因此可以向该材料中加载大量的As（III）-药物（以亚砷酸的形式））。此外，我们还研究了在不同pH值下的药物释放。明显地，我们观察到，As（III）的释放是通过pH触发的，在pH 6.0时比在pH 7.4时更快。因此，我们建议使用Zn-MOF-74作为MOF的模型示例，该MOF包含开放的金属位点以控制药物的装载和输送。

更新日期：2020-06-16

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