Cu/PCy3‐Catalyzed Formal Carbene Insertion into Electron‐Deficient C−H Bonds,ChemCatChem

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Cu/PCy3‐Catalyzed Formal Carbene Insertion into Electron‐Deficient C−H Bonds
ChemCatChem ( IF 3.8 ) Pub Date : 2020-05-28 , DOI: 10.1002/cctc.202000684
Yuan‐Yuan Ren ₁ , Hong‐Xiang Mao ₁ , Meng‐Yang Hu ₁ , Shou‐Fei Zhu ₁ , Qi‐Lin Zhou ₁

Affiliation

A carbene insertion into electron‐deficient C−H bonds of 1,3‐diesters, β‐ketoesters, β‐ketonitriles, and malononitriles was realized by using CuCN/PCy₃ as the catalyst. The reaction provides a straightforward approach to the synthetically important multi‐substituted succinic acid derivatives. A plausible reaction mechanism with cyclopropanation/ring opening as key steps was proposed based on control experiments.

中文翻译：

Cu / PCy3催化形式的碳插入到缺电子的CH键中

通过使用CuCN / PCy ₃作为催化剂，将卡宾插入到1,3-二酯，β-酮酸酯，β-酮腈和丙二腈的电子不足的CH键中。该反应为合成上重要的多取代琥珀酸衍生物提供了一种直接方法。在控制实验的基础上，提出了以环丙烷化/开环为关键步骤的合理反应机理。

更新日期：2020-05-28

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