Abstract Prostate cancer is one of the most common cancers affecting men. Bone scan is part of the staging modality commonly used to evaluate bone metastasis. A bone scan with diffused increased skeletal tracer uptake relative to soft tissue, combined with faint renal activity is known as a superscan. However, a primary concern are false negatives associated with bone scans, where diffuse metastasis is indistinguishable on superscans. In this study, we performed xSPECT/CT Bone and standard OSEM SPECT/CT reconstruction algorithm in ten prostate cancer patients with high PSA levels, where they initially seem relatively unremarkable on planar images. All patients with extensive bone metastases showed either relatively unremarkable scans or did not demonstrate the true extent of metastatic burden as seen on planar images. Uptake was further confirmed by the correlative diffuse bone lesions on CT images. Our reports also indicated that xSPECT/CT reconstructed images were far superior in delineating focal areas of osteoblastic bone metastasis, when compared with whole body planar images or SPECT/CT images. The extent of metastatic evidence is delineated with excellent clarification by xSPECT/CT images. We propose that whole body xSPECT/CT image reconstruction, or at least SPECT/CT, should be performed in patients with high PSA levels, along with planar imaging, to improve diagnostic accuracy of bone scans in prostate cancer staging.

中文翻译：

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Superscan：在前列腺癌患者的骨扫描中，xSPECT/CT 优于 OSEM SPECT/CT。

摘要 前列腺癌是影响男性的最常见癌症之一。骨扫描是常用于评估骨转移的分期方式的一部分。具有相对于软组织的骨骼示踪剂吸收增加的弥散性骨扫描，结合微弱的肾脏活动被称为超级扫描。然而，主要关注的是与骨扫描相关的假阴性，其中弥漫性转移在超级扫描上无法区分。在本研究中，我们对 10 名具有高 PSA 水平的前列腺癌患者执行了 xSPECT/CT Bone 和标准 OSEM SPECT/CT 重建算法，这些患者最初在平面图像上看起来相对不显眼。所有具有广泛骨转移的患者要么表现出相对不显着的扫描，要么没有表现出在平面图像上看到的转移负担的真实程度。CT 图像上的相关弥漫性骨病变进一步证实了摄取。我们的报告还表明，与全身平面图像或 SPECT/CT 图像相比，xSPECT/CT 重建图像在描绘成骨细胞骨转移的病灶区域方面要优越得多。转移证据的范围通过 xSPECT/CT 图像进行了出色的澄清。我们建议对 PSA 水平高的患者进行全身 xSPECT/CT 图像重建，或至少是 SPECT/CT，并进行平面成像，以提高骨扫描在前列腺癌分期中的诊断准确性。与全身平面图像或 SPECT/CT 图像相比。转移证据的范围通过 xSPECT/CT 图像进行了出色的澄清。我们建议对 PSA 水平高的患者进行全身 xSPECT/CT 图像重建，或至少是 SPECT/CT，并进行平面成像，以提高骨扫描在前列腺癌分期中的诊断准确性。与全身平面图像或 SPECT/CT 图像相比。xSPECT/CT 图像可以很好地阐明转移证据的范围。我们建议对 PSA 水平高的患者进行全身 xSPECT/CT 图像重建，或至少是 SPECT/CT，并进行平面成像，以提高骨扫描在前列腺癌分期中的诊断准确性。