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Miliusins; cytotoxic neolignans from the leaves of Miliusa sessilis
Phytochemistry ( IF 3.2 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.phytochem.2020.112417 Yupa Pootaeng-On 1 , Purin Charoensuksai 2 , Pawaris Wongprayoon 2 , Suwadee Jiajaroen 3 , Kittipong Chainok 3 , Kanok-On Rayanil 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.phytochem.2020.112417 Yupa Pootaeng-On 1 , Purin Charoensuksai 2 , Pawaris Wongprayoon 2 , Suwadee Jiajaroen 3 , Kittipong Chainok 3 , Kanok-On Rayanil 1
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Eight undescribed neolignans and an undescribed propanoid dimer were isolated from the leaves of Miliusa sessilis, together with two known compounds, dehydrodieugenol A and dehydrodieugenol B. All structures were elucidated by extensive spectroscopic data analysis and the structure of (7S,8R)-5'-hydroxy-3,4-dimethoxy-4',7-epoxy-8,3'-neolign-8'-en-9-acetate (miliusin A) was further confirmed by X-ray crystallographic analysis. The absolute configurations were determined using circular dichroism (CD) data analysis and the modified Mosher's method. All isolated compounds were evaluated for their cytotoxic activities against four human cancer cell lines (HeLa, HN22, HepG2, and HCT116), including one normal-type cell line (HaCaT) using MTT assay. (7S,8R)-5'-hydroxy-3,4-dimethoxy-4',7-epoxy-8,3'-neolign-8'-en-9-ol (miliusin B) was found to exhibit the most promising cytotoxic effect against Hela cells with the lowest IC50 value of 0.04 μM and the highest selective index of 187.8, highlighting miliusin B as an attractive candidate for cervical cancer drug development.
中文翻译：
米留辛；来自 Miliusa sessilis 叶子的细胞毒性新木脂素
从 Miliusa sessilis 的叶子中分离出八种未描述的新木脂素和一种未描述的丙烷二聚体，以及两种已知的化合物，脱氢二丁香酚 A 和脱氢二丁香酚 B。通过广泛的光谱数据分析和 (7S,8R)-5' 的结构阐明了所有结构-羟基-3,4-二甲氧基-4',7-epoxy-8,3'-neolig-8'-en-9-acetate (miliusin A) 通过 X 射线晶体学分析进一步证实。使用圆二色性 (CD) 数据分析和改进的 Mosher 方法确定绝对构型。使用 MTT 测定法评估了所有分离的化合物对四种人类癌细胞系（HeLa、HN22、HepG2 和 HCT116）的细胞毒活性，其中包括一种正常型细胞系 (HaCaT)。(7S,8R)-5'-羟基-3,4-二甲氧基-4',7-环氧-8,3'-neoign-8'
更新日期：2020-08-01
中文翻译：
米留辛；来自 Miliusa sessilis 叶子的细胞毒性新木脂素
从 Miliusa sessilis 的叶子中分离出八种未描述的新木脂素和一种未描述的丙烷二聚体，以及两种已知的化合物，脱氢二丁香酚 A 和脱氢二丁香酚 B。通过广泛的光谱数据分析和 (7S,8R)-5' 的结构阐明了所有结构-羟基-3,4-二甲氧基-4',7-epoxy-8,3'-neolig-8'-en-9-acetate (miliusin A) 通过 X 射线晶体学分析进一步证实。使用圆二色性 (CD) 数据分析和改进的 Mosher 方法确定绝对构型。使用 MTT 测定法评估了所有分离的化合物对四种人类癌细胞系（HeLa、HN22、HepG2 和 HCT116）的细胞毒活性，其中包括一种正常型细胞系 (HaCaT)。(7S,8R)-5'-羟基-3,4-二甲氧基-4',7-环氧-8,3'-neoign-8'
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