Maternal exposure to infectious agents such as arboviruses, bacteria, or other protozoans has been associated with an elevated risk of schizophrenia (SZ). Evidence suggests that immunological processes occurring during infection may disturb the neural progenitor, impacting the central nervous system (CNS) functions. Moreover, growing evidence suggests that resveratrol (RSV) has neuroprotective activity through anti-oxidant and anti-inflammatory mechanisms. Therefore, we investigated if the treatment with RSV during pregnancy would prevent the abnormalities associated with a SZ-like phenotype induced by maternal immune activation (MIA). Pregnant dams stimulated with a subcutaneous (s.c.) injection of polyriboinosinic-polyribocytidylic acid (poly I:C; 50 mg/kg), a viral nucleic acid mimetic or vehicle, on gestational day (GD) 12.5, were treated with RSV (40 mg/kg, s.c.) or saline, from GD 9.5 to GD 14.5. On day 45 after birth, the offspring was evaluated using a three-compartment social interaction test, elevated plus maze, and hyperlocomotion test induced by amphetamine. After the behavioral tests, the relative expression of mRNA to synapsin 1 (Syn1), oligodendrocyte transcription factor 1 (Olig1), and SRY (sex-determining region Y)-box 2 (Sox2) was determined in the hippocampus and cortex. Treatment with RSV restored the social behavior and attenuated the hyperlocomotion of the offspring bred by dams submitted to MIA. RSV prevented the effects of MIA on Syn1 and Olig1 expression in the hippocampus and Syn1 in the cortex. The present study showed that maternal treatment with RSV attenuates some of the negative behavioral impacts caused by MIA, with modulation of synaptic and oligodendrogenesis processes.

孕产妇接触虫媒病毒，细菌或其他原生动物等传染原与精神分裂症（SZ）的风险升高有关。有证据表明，感染期间发生的免疫过程可能会干扰神经祖细胞，从而影响中枢神经系统（CNS）的功能。此外，越来越多的证据表明白藜芦醇（RSV）通过抗氧化和抗炎机制具有神经保护活性。因此，我们调查了妊娠期用RSV进行的治疗是否可以预防由母体免疫激活（MIA）诱导的SZ样表型相关的异常。在妊娠第12.5天，皮下注射皮下注射多核糖核酸聚核糖核酸（poly I：C； 50 mg / kg），病毒核酸模拟物或媒介物刺激怀孕的母坝，用RSV（40 mg / kg，sc）或生理盐水处理（GD 9.5至GD 14.5）。出生后第45天，使用三室社交互动测试，高架迷宫和苯丙胺诱导的运动过度测试对后代进行评估。行为测试后，确定海马和皮层中mRNA与突触蛋白1（Syn1），少突胶质细胞转录因子1（Olig1）和SRY（性决定区Y）-box 2（Sox2）的相对表达。RSV的治疗恢复了社会行为，并减弱了由提交给MIA的水坝繁育的后代的超运动能力。RSV阻止了MIA对海马中Syn1和Olig1表达以及皮质中Syn1的影响。本研究表明，产妇接受RSV治疗可减轻MIA引起的某些负面行为影响，