Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g dw), total flavonoid content (252 mg CE/100 g dw), total proanthocyanidin content (295 mg CE/100 g dw), and corresponding total antioxidant activity. However, the maximum anti-proliferative activity against colon cancer cell lines (HT29 and HCT116) was shown in a Sichuan cultivar (SC-1) and the maximum anti-proliferative activity against breast cancer cell line (MCF7) was shown in a Heilongjiang cultivar (HJ-1). Antioxidant activity was significantly associated with total phenolics, total flavonoids, and total proanthocyanidins, while anti-proliferative activity of extracts had no correlation with total phenolic contents and in vitro antioxidant activity. In addition, common bean extracts reduced intracellular ROS level. A total of 17 phytochemical compounds were tentatively characterized in the extracts. These results will provide a reference for improving the value of common beans and contribute to the cultivar selection of the common bean cultivars for human health.

在10个普通豆品种中测量并比较了普通豆提取物的抗氧化，抗增殖活性和植物化学特性。在这些品种中，云南品种（YN-1）的总酚含量最高（423 mg GAE / 100 g dw），总黄酮含量（252 mg CE / 100 g dw），原花色素总含量（295 mg CE / 100） g dw）和相应的总抗氧化剂活性。但是，四川品种（SC-1）对结肠癌细胞系（HT29和HCT116）的最大抗增殖活性，黑龙江品种对乳腺癌细胞系（MCF7）的最大抗增殖活性（HJ-1）。抗氧化剂活性与总酚，总黄酮和总原花青素显着相关，体外抗氧化活性。另外，普通豆提取物降低了细胞内ROS水平。提取物中初步鉴定了总共17种植物化学化合物。这些结果将为提高普通豆的价值提供参考，并有助于为人类健康选择普通豆的品种。