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Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity
Food Bioscience ( IF 4.8 ) Pub Date : 2020-05-28 , DOI: 10.1016/j.fbio.2020.100662
Qiong-Qiong Yang , Arakkaveettil Kabeer Farha , Lizeng Cheng , Gowoon Kim , Tongze Zhang , Harold Corke

Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g dw), total flavonoid content (252 mg CE/100 g dw), total proanthocyanidin content (295 mg CE/100 g dw), and corresponding total antioxidant activity. However, the maximum anti-proliferative activity against colon cancer cell lines (HT29 and HCT116) was shown in a Sichuan cultivar (SC-1) and the maximum anti-proliferative activity against breast cancer cell line (MCF7) was shown in a Heilongjiang cultivar (HJ-1). Antioxidant activity was significantly associated with total phenolics, total flavonoids, and total proanthocyanidins, while anti-proliferative activity of extracts had no correlation with total phenolic contents and in vitro antioxidant activity. In addition, common bean extracts reduced intracellular ROS level. A total of 17 phytochemical compounds were tentatively characterized in the extracts. These results will provide a reference for improving the value of common beans and contribute to the cultivar selection of the common bean cultivars for human health.



中文翻译:

普通豆(菜豆)中的酚含量和体外抗氧化活性与抗增殖活性没有直接关系

在10个普通豆品种中测量并比较了普通豆提取物的抗氧化,抗增殖活性和植物化学特性。在这些品种中,云南品种(YN-1)的总酚含量最高(423 mg GAE / 100 g dw),总黄酮含量(252 mg CE / 100 g dw),原花色素总含量(295 mg CE / 100) g dw)和相应的总抗氧化剂活性。但是,四川品种(SC-1)对结肠癌细胞系(HT29和HCT116)的最大抗增殖活性,黑龙江品种对乳腺癌细胞系(MCF7)的最大抗增殖活性(HJ-1)。抗氧化剂活性与总酚,总黄酮和总原花青素显着相关,体外抗氧化活性。另外,普通豆提取物降低了细胞内ROS水平。提取物中初步鉴定了总共17种植物化学化合物。这些结果将为提高普通豆的价值提供参考,并有助于为人类健康选择普通豆的品种。

更新日期:2020-05-28
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