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Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma.
Cancer Cell ( IF 48.8 ) Pub Date : 2020-05-28 , DOI: 10.1016/j.ccell.2020.05.009 Guido Kroemer 1 , Laurence Zitvogel 2
中文翻译:
寻求细胞健康和免疫逃避:胰腺癌中的自噬。
更新日期:2020-05-28
Cancer Cell ( IF 48.8 ) Pub Date : 2020-05-28 , DOI: 10.1016/j.ccell.2020.05.009 Guido Kroemer 1 , Laurence Zitvogel 2
Affiliation
In a recent Nature paper, Yamamoto et al. demonstrate that, in the particular context of pancreatic carcinoma, autophagy causes the continuous destruction of major histocompatibility complex class I (MHC-I) proteins. Suppression of autophagy favors MHC-I re-appearance on the surface of malignant cells, facilitating their clearance by cytotoxic T lymphocytes.
中文翻译:
寻求细胞健康和免疫逃避:胰腺癌中的自噬。
在最近的一篇《自然》论文中,Yamamoto 等人。证明,在胰腺癌的特定背景下,自噬导致主要组织相容性复合物 I 类 (MHC-I) 蛋白的持续破坏。自噬的抑制有利于 MHC-I 在恶性细胞表面重新出现,从而促进细胞毒性 T 淋巴细胞将其清除。