Malignant conversion of cancer cells requires efficient mitochondria reprogramming orchestrated by hundreds of genes. The transformation includes increased energy demand, biosynthesis of precursors, and reactive oxygen species needed to accelerate cell growth, proliferation, and survival. Reprogramming involves complex gene alterations that have not been methodically curated. Therefore, we systematically analyzed the literature of cancer-related genes in mitochondria. Through the analysis of >2500 PubMed abstracts and >1600 human genes, we identified 228 genes showing clear roles in cancer. Each gene was classified according to their homeostatic function, together with the pathological transitions that contribute to specific cancer hallmarks. The potential clinical relevance of these hallmarks and genes is discussed by representative examples and validated by detecting differences in gene expression levels across 16 different types of cancer. A compendium, including the gene functions and alterations underpinning cancer progression, can be explored at http://bioinformatica.mty.itesm.mx/MitoCancer.

癌细胞的恶性转化需要数百种基因精心策划的有效线粒体重编程。转化包括增加的能量需求，前体的生物合成以及促进细胞生长，增殖和存活所需的活性氧。重编程涉及尚未系统整理的复杂基因改变。因此，我们系统地分析了线粒体中与癌症相关的基因的文献。通过分析> 2500个PubMed摘要和> 1600个人类基因，我们确定了228个在癌症中显示明确作用的基因。根据每个基因的稳态功能以及有助于特定癌症特征的病理转变对每个基因进行分类。这些特征和基因的潜在临床相关性将通过代表性实例进行讨论，并通过检测16种不同类型癌症的基因表达水平差异来验证。可以在http://bioinformatica.mty.itesm.mx/MitoCancer上探索一个纲要，包括支持癌症进展的基因功能和改变。