Background

Selenoproteins S (SELS or VIMP) may regulate cytokine production, and thus play a key role in the control of the inflammatory response.

Methods

This study consisted of 136 Iranian patients with cardiovascular disease (65 MetS-affected and 71 MetS un-affected individuals) in the selengene study. Expression of two variants of VIMP including VIMP I and II were analyzed in all subjects using Real-Time PCR and ELISA.

Results

The level of VIMP was lower in MetS⁺ compared to the MetS⁻ subjects (p <0.05). We found no significant differences in quantitative expression of VIMP I and VIMP II in both groups. VIMP I reveal a reverse correlation with fasting blood sugar (FBS) (r = −0.45, p = 0.009). Moreover, SELS in protein level has negative correlation with WC (r = −0.171, p = 0.049) and positive correlation with HDL (r = 0.176, p = 0.046).

Conclusions

Our study suggests that VIMP in protein level is significantly lower in MetS and shows a reverse correlation with WC and positive correlation with HDL. Therefore, with regard to the functional role of this protein, it is possible to deduce that its lower expression leads to the higher secretion of unfolded proteins into the cytosol and outside the cell, where they cannot play their exact roles in the different pathways. Moreover, the reverse correlation of VIMP I with FBS suggests further consideration of VIMP and its variant VIMP I expression in regards to potential development of major CVD risk factors.

中文翻译：

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心血管疾病患者中硒蛋白S表达及其变异与代谢综合征的相关性。

背景

硒蛋白S（SELS或VIMP）可能调节细胞因子的产生，因此在控制炎症反应中起关键作用。

方法

该研究由selengene研究中的136名伊朗心血管病患者（65名受MetS影响的患者和71名未受MetS影响的患者）组成。使用实时PCR和ELISA在所有受试者中分析了包括VIMP I和II在内的两种VIMP变体的表达。

结果

VIMP的水平在较低的MetS ⁺相比，代谢综合征^-受试者（p  <0.05）。我们发现两组中VIMP I和VIMP II的定量表达没有显着差异。VIMP I揭示了与空腹血糖（FBS）呈负相关（r  = -0.45，p  = 0.009）。此外，蛋白质水平上的SELS与WC呈负相关（r  = -0.171，p  = 0.049），与HDL呈正相关（r  = 0.176，p  = 0.046）。

结论

我们的研究表明，在MetS中，蛋白质水平的VIMP显着降低，并且与WC呈反相关，与HDL呈正相关。因此，关于该蛋白质的功能作用，有可能推论其较低的表达导致未折叠的蛋白质更多地分泌到胞质溶胶中和细胞外，而它们不能在不同的途径中发挥其确切的作用。此外，VIMP I与FBS的反向相关性暗示了在主要CVD危险因素的潜在发展方面对VIMP及其变体VIMP I表达的进一步考虑。