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Magnetic Nanoparticles as a Strong Contributor to the Biocompatibility of Ferrogels
Physics of Metals and Metallography ( IF 1.1 ) Pub Date : 2020-05-19 , DOI: 10.1134/s0031918x2004002x
F. A. Blyakhman , E. B. Makarova , P. A. Shabadrov , F. A. Fadeyev , T. F. Shklyar , A. P. Safronov , S. V. Komogortsev , G. V. Kurlyandskaya

Abstract

Biomedical engineering is the most promising field for the application of ferrogels as scaffolds for cell culturing in regenerative medicine, targeted drug delivery, and biosensorics. This study is focused on the contribution of ferric-oxide magnetic nanoparticles (MNPs) to the biocompatibility of ferrogels with human dermal fibroblasts. The results of experiments with polyacrylamide gels filled with MNPs are presented. These experiments demonstrate that, regardless of the mechanical and electrical characteristics of ferrogels, MNPs have a significant effect on the biological activity of cells.



中文翻译:

磁性纳米粒子是费洛格尔生物相容性的强力贡献者

摘要

生物医学工程学是最有前途的领域,其将铁蛋白用作在再生医学,靶向药物递送和生物传感中用于细胞培养的支架。这项研究的重点是三氧化二铁磁性纳米颗粒(MNP)对铁蛋白与人皮肤成纤维细胞的生物相容性的贡献。给出了填充有MNP的聚丙烯酰胺凝胶的实验结果。这些实验表明,不管铁蛋白的机械和电气特性如何,MNP对细胞的生物学活性都有重要影响。

更新日期:2020-05-19
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