Abstract

Chemoselective domino ring opening and selective O/S-alkylation of ethers/thioethers over enol C/O alkylation has been observed. Various 2-aryl chromanones/thiochromanones with alkyl/allyl bromides were smoothly converted into the corresponding highly functionalized ethers and thioethers in excellent yields with high selectivity.

Graphic abstract

An unusual, chemoselective domino ring opening and selective ether/thioether O/S-alkylation over. An unusual, chemoselective domino ring opening and selective ether/thioether O/S alkylation over enol C/O alkylation has been observed.

中文翻译：

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环醚和硫醚的多米诺开环和选择性 O/S-烷基化。

摘要

已经观察到与烯醇 C/O 烷基化相比，醚/硫醚的化学选择性多米诺开环和选择性 O/S-烷基化。各种具有烷基/烯丙基溴的 2-芳基色满酮/硫杂色满酮以优异的收率和高选择性顺利转化为相应的高度官能化的醚和硫醚。

图形摘要

一种不寻常的化学选择性多米诺开环和选择性醚/硫醚 O/S-烷基化。已观察到与烯醇 C/O 烷基化相比，不寻常的化学选择性多米诺开环和选择性醚/硫醚 O/S 烷基化。