Persons with drug refractory TLE have the option of being managed by surgery. They may develop memory impairment with specific etiology of mesial temporal sclerosis and anterior temporal lobe resection (ATLR). The study evaluated the semantic verbal memory outcomes in pre- and post-surgery temporal lobe epilepsy (TLE) patients using functional MRI and voxel morphometric methods. Twenty consecutive persons with drug-resistant epilepsy (DRE) and 20 healthy controls were recruited after obtaining the institute ethics approval. The fMRI scans were performed on a 1.5 T MR Scanner using standardized semantic verbal memory tasks using a native Hindi paradigm, before and after an anterior temporal lobectomy (in cases). A task-based functional connectivity (FC) was estimated using a conn toolbox. Data analysis was carried out using the statistical parametric imaging (SPM12) and CAT12 toolbox. Post-surgery TLE group showed increased robust FC in the right middle and posterior temporal regions as compared to pre-surgery session. A significant reduction in grey matter volume was observed in the left temporal lobe post-operatively as compared to pre-surgery and healthy control groups. In the post-surgery TLE group, neuropsychological scores were reduced in specific PGI domains such as visuospatial, working memory, and executive functioning. Our results may help in understanding of memory reorganization in TLE post-operatively.

中文翻译：

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内侧颞叶硬化患者的记忆评估：fMRI 和 VBM 联合研究

患有药物难治性 TLE 的人可以选择接受手术治疗。他们可能会因颞叶内侧硬化和前颞叶切除术 (ATLR) 的特定病因而出现记忆障碍。该研究使用功能性 MRI 和体素形态测量方法评估了手术前和手术后颞叶癫痫 (TLE) 患者的语义语言记忆结果。在获得研究所伦理批准后，连续招募了 20 名耐药性癫痫 (DRE) 患者和 20 名健康对照者。fMRI 扫描是在 1.5 T MR 扫描仪上使用标准化语义语言记忆任务使用原生印地语范式在前颞叶切除术之前和之后进行的（在病例中）。使用 conn 工具箱估计基于任务的功能连接 (FC)。使用统计参数成像 (SPM12) 和 CAT12 工具箱进行数据分析。与手术前相比，手术后 TLE 组显示右侧中颞区和后颞区的 FC 增加。与手术前和健康对照组相比，术后左侧颞叶的灰质体积显着减少。在术后 TLE 组中，特定 PGI 领域的神经心理学评分降低，如视觉空间、工作记忆和执行功能。我们的结果可能有助于理解 TLE 术后记忆重组。与手术前和健康对照组相比，术后左侧颞叶的灰质体积显着减少。在术后 TLE 组中，特定 PGI 领域的神经心理学评分降低，如视觉空间、工作记忆和执行功能。我们的结果可能有助于理解 TLE 术后记忆重组。与手术前和健康对照组相比，术后左侧颞叶的灰质体积显着减少。在术后 TLE 组中，特定 PGI 领域的神经心理学评分降低，如视觉空间、工作记忆和执行功能。我们的结果可能有助于理解 TLE 术后记忆重组。