Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

用透明质酸（HA）和羧甲基纤维素（CMC）的混合物制备了可口分散膜（ODF），并研究了添加CMC对复合膜的崩解和力学性能的影响。与高分子量HA（800 kDa）相比，低分子量HA（10 kDa）对ODF的接受程度更高，因为它在口腔中迅速崩解。复合膜看起来与支链淀粉膜相似，具有优异的透明度和表面光滑度。加入CMC可以增加薄膜的崩解时间和机械性能，例如拉伸强度和断裂伸长率。总体而言，CMC的添加量高达35％，在适当的ODF崩解时间范围内，改善了低分子量HA膜的机械性能。