This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer.

中文翻译：

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化学功能化双电极表面上的 MicroRNA-155 互补，用于确定乳腺癌。

这项研究将 microRNA-155 的表达与乳腺癌相关联并进行量化，以确定乳腺癌的进展。通过在捕获探针序列固定的叉指双电极表面上的互补来鉴定目标 microRNA-155 序列。灵敏度为 1 fM，检测限在 1 至 10 fM 之间。单错配、三重错配和非互补碱基的特定序列选择性未能与捕获探针序列互补。获得的结果证明了microRNA-155序列的选择性测定，有助于乳腺癌的诊断。