Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG/HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-h ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24 h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex. Our study included 70 children (65.71% boys and 34.29% girls) median age (14 years, IQR = 12–16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24 h-average SBP with LVMI (effect = 3.65, SE = 1.32, p < 0.01; effect = 34.90, SE = 6.84, p < 0.01; effect = 0.32, SE = 0.12, p < 0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect = 13.07, SE = 5.02, p = 0.01 Insulin: effect = 2.80, SE = 0.97). Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

中文翻译：

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肥胖儿童的脂质分布和左心室几何形态。

左心室肥大（LVH）是心血管和全因死亡率的重要危险因素。先前的研究报道了有关血脂水平和左心室几何形态之间关系的矛盾结果。我们试图探讨肥胖儿童标准血清脂质谱测量与左心室几何形态之间的关系。在这项横断面研究中，总共检查了70名肥胖儿童。抽取空腹血样以测量总胆固醇，低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），甘油三酸酯（TGs），葡萄糖和胰岛素。基于这些值TG / HDL比，计算BMI和HOMA指数。我们还测量了平均24小时门诊收缩压（SBP），并进行了二维（2 / D）经胸超声心动图检查以确定左心室质量指数（LVMI）和相对壁厚（RWT）。进行了多元回归分析，以探讨研究变量与作为结果变量的LVMI或RWT之间的关系。最终的LVMI模型包括TG / HDL比，BMI，24 h平均SBP，年龄和性别，而对于RWT，我们包括BMI，胰岛素，年龄和性别。我们的研究包括70名中位年龄（14岁，IQR = 12-16）的儿童（男孩为65.71％，女孩为34.29％）。”我们证明了TG / HDL比率，BMI和24 h平均SBP与LVMI呈独立正相关（影响= 3.65，SE = 1.32，p <0.01；影响= 34.90，SE = 6.84，p <0.01；影响= 0.32，SE = 0.12，p <0.01）。另一方面，在以RWT作为结果变量的模型中，只有BMI和胰岛素显着相关（BMI：作用= 13.07，SE = 5.02，p = 0.01胰岛素：作用= 2.80，SE = 0.97）。肥胖儿童的TG / HDL比值增加与偏心左心室肥大的发展有关，而BMI和胰岛素增加与同心性左心室肥厚有关。