A new series of indole-based-sulfonamide derivatives (A1–A8) was synthesized by treating 5-fluoro-1H-indole-3-carbohydrazide with different aryl-sulfonyl chloride in the presence of pyridine. All synthesized derivatives (A1–A8) were characterized by different analytical methods. The electrochemical behavior of these compounds (A1–A8) was investigated in detail using cyclic voltammetry (CV) and square wave voltammetry (SWV) at the pencil graphite electrode (PGE). In the present study, the redox behavior of all derivatives varies due to the nature of substitutions in the indole sulfonamide moiety. Various fundamental electrochemical parameters, including the standard heterogeneous rate constants (ks), and the electroactive surface coverage (Г) were calculated from the obtained CVs. The obtained results shed light on the understanding of structure–activity relationships of this class of compounds.

中文翻译：

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一些生物学上重要的基于吲哚的磺酰胺衍生物的合成，表征和电化学性质。

在吡啶存在下，用不同的芳基磺酰氯处理5-氟代-1H-吲哚-3-碳酰肼，合成了一系列新的基于吲哚的磺酰胺衍生物（A1-A8）。所有合成的衍生物（A1-A8）的分析方法都不同。使用循环伏安法（CV）和方波伏安法（SWV）在铅笔石墨电极（PGE）上详细研究了这些化合物（A1-A8）的电化学行为。在本研究中，由于吲哚磺酰胺部分的取代性质，所有衍生物的氧化还原行为都不同。由获得的CV计算出各种基本的电化学参数，包括标准的异质速率常数（ks）和电活性表面覆盖率（Г）。