Regioselective and Diastereoselective Dearomative Multifunctionalization of In-Situ-Activated Azaarenes: An Access to Bridged Azaheterocycles.,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Regioselective and Diastereoselective Dearomative Multifunctionalization of In-Situ-Activated Azaarenes: An Access to Bridged Azaheterocycles.
Organic Letters ( IF 4.9 ) Pub Date : 2020-05-27 , DOI: 10.1021/acs.orglett.0c01648
Xu-Guan Bai ₁ , Hong-Jie Miao ₁ , Yang Zhao ₁ , Qi-Lin Wang ₁ , Zhan-Wei Bu ₁

Affiliation

Reported herein is an unprecedented multicomponent one-pot dearomative multifunctionalization of commercially available azaarenes through an in situ activation strategy, which not only achieved the first full exploitation of the reactive sites of the azaarenes, but also accomplished the efficient synthesis of bridged hydrogenated pyridines and (iso)quinolines in a highly regioselective and diastereoselective manner. In addition, we could successfully realize the step-controlled dearomative trifunctionalization and bifunctionalization of quinolines.

中文翻译：

原位激活的氮杂芳烃的区域选择性和非对映选择性脱芳香性多功能化：桥接桥接的Azaheterocycles。

本文报道的是一种通过原位活化策略实现的市售氮杂芳烃前所未有的多组分单锅脱芳香化多功能化，不仅实现了氮杂芳烃反应位点的首次充分利用，而且还实现了桥联氢化吡啶和（异）喹啉具有高度区域选择性和非对映选择性的方式。此外，我们可以成功实现喹啉的分步控制脱芳香三官能化和双官能化。

更新日期：2020-07-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11