To explore whether the expression levels of viral-entry associated genes might contribute to the milder symptoms in children, we analysed the expression of these genes in both children and adults' lung tissues by single cell RNA sequencing (scRNA-seq) and immunohistochemistry (IHC). Both scRNA-seq and IHC analyses showed comparable expression of the key genes for SARS-CoV-2 entry in children and adults, including ACE2, TMPRSS2 and FURIN, suggesting that instead of lower virus intrusion rate, other factors are more likely to be the key reasons for the milder symptoms of SARS-CoV-2 infected children.

中文翻译：

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儿童肺组织scRNA测序的初步分析排除了SARS-CoV-2进入相关基因的表达，这是儿童COVID-19轻度综合征的关键原因

为了探讨病毒进入相关基因的表达水平是否可能导致儿童轻度症状，我们通过单细胞RNA测序（scRNA-seq）和免疫组织化学（IHC）分析了这些基因在儿童和成人肺组织中的表达。 ）。scRNA-seq和IHC分析均显示儿童和成人中SARS-CoV-2进入关键基因的可比表达，包括ACE2，TMPRSS2和FURIN，这表明除了较低的病毒入侵率外，其他因素更可能是SARS-CoV-2感染儿童症状较轻的主要原因。