Compulsivity and loss of behavioral control represent core symptoms in obsessive-compulsive disorder (OCD), substance use disorder (SUD), and internet gaming disorder (IGD). Despite animal models suggesting compulsivity mediated by cortico-striatal circuits and several neuroimaging case-control studies positing common/distinct neurofunctional alterations in these disorders a systematic examination is still lacking. The present study capitalized on previous case-control fMRI studies to determine shared and disorder-specific neurofunctional alterations among three disorders. Task-based fMRI studies in SUD, OCD, and IGD were obtained. Coordinate-based meta-analyses were performed within each disorder. Next contrast and conjunction meta-analyses were done to determine differential and common neurofunctional alterations between the disorders. Task-paradigm were group according to RDoC domains to determine contributions of underlying behavioral domains. Find pre-registration of the study here (https://osf.io/j8wct/). 144 articles were included representing 6897 individuals (SUD=2418, controls=2332; IGD=361, controls=360; OCD=715, controls=711). Conjunction meta-analyses revealed shared alterations in anterior insular cortex between OCD, and pooled as-well-as separate SUDs. SUD exhibited pronounced dorso-striatal alterations as compared to both, OCD and IGD. IGD shared frontal, particularly cingulate alterations with all SUDs. IGD demonstrated temporal alterations compared to both, SUD and OCD. No robust overlap between IGD and OCD was observed. Across the disorders, neurofunctional alterations were mainly contributed to by cognitive systems and positive valence RDoC domains. The present findings indicate that neurofunctional dysregulations in prefrontal regions engaged in regulatory control share neurofunctional alterations across substance and behavioral addictions, while shared neurofunctional dysregulations in the anterior insula may mediate compulsivity in substance addiction and obsessive-compulsive disorders.

中文翻译：

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常见和可分离的神经功能失调是强迫症，药物滥用和游戏障碍的特征-功能成像研究的激活可能性荟萃分析的证据

强迫性和行为控制力丧失是强迫症（OCD），物质使用障碍（SUD）和互联网游戏障碍（IGD）的核心症状。尽管动物模型提示由皮质纹状体-纹状体回路介导的强迫性，并且一些神经影像学病例对照研究提出了这些疾病常见/不同的神经功能改变，但仍缺乏系统的检查。本研究利用以前的病例对照功能磁共振成像研究来确定三种疾病之间共享的和特定于疾病的神经功能改变。在SUD，OCD和IGD中获得了基于任务的功能磁共振成像研究。在每种疾病中进行基于坐标的荟萃分析。接下来进行对比和联合荟萃分析，以确定疾病之间的差异和常见神经功能改变。根据RDoC域对任务范式进行分组，以确定潜在行为域的贡献。在此处查找研究的预注册（https://osf.io/j8wct/）。包括144个文章，代表6897个个体（SUD = 2418，对照= 2332； IGD = 361，对照= 360； OCD = 715，对照= 711）。合并荟萃分析显示，强迫症之间的前岛皮层有共同的改变，并合并了单独的SUD。与OCD和IGD相比，SUD表现出明显的背纹状体改变。IGD与所有SUD共享额叶，尤其是扣带式变化。与SUD和OCD相比，IGD表现出时间变化。在IGD和OCD之间未观察到牢固的重叠。在各种疾病中，神经功能的改变主要是由认知系统和正价RDoC域引起的。