Following a stroke, the brain undergoes a process of neuronal reorganization to compensate for structural damage and cope with functionality loss. Increases in stroke-induced neurogenesis rates in the dentate gyrus and neural migration from the hippocampus towards the affected site have been observed, suggesting that the hippocampus is involved in functionality gains and neural reorganization. Despite the observed hippocampal contributions to structural changes, the hippocampal physiology for stroke recovery has been poorly characterized. To this end, we measured resting-state whole-brain activity from non-hippocampal stroke survivors (n=13) during functional MRI scanning. Analysis of multiple hippocampal subregions revealed that the voxel activity of hippocampal readout sites (CA1 and subiculum) forecast the patient's chronicity stage stronger than early regions of the hippocampal circuit. Furthermore, we observed hemispheric-specific contributions to chronicity forecasting, raising the hypothesis that left and right hippocampus are functionally dissociable during recovery. In addition, we suggest that in contrast with whole-brain analysis, the monitoring of segregated and specialized sub-networks after stroke potentially reveals detailed aspects of stroke recovery. Altogether, our results shed light on the contribution of the subcortical-cortical interplay for neural reorganization and highlight new avenues for stroke rehabilitation.

中文翻译：

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人CA1和下呼吸活动预测中风慢性

中风后，大脑会经历神经元重组过程，以补偿结构性损伤并应对功能丧失。观察到中风引起的齿状回中神经元发生率的增加以及从海马向受影响部位的神经迁移，这表明海马参与了功能增强和神经重组。尽管观察到海马对结构变化的贡献，但对于中风恢复的海马生理学却知之甚少。为此，我们在功能性MRI扫描期间测量了来自非海马中风幸存者（n = 13）的静止状态全脑活动。对多个海马亚区的分析表明，海马读数位点（CA1和下丘脑）的体素活动可预测患者的 的慢性期强于海马回路的早期区域。此外，我们观察到半球特异性对慢性病的预测，提出了在恢复过程中左右海马在功能上可分离的假设。此外，我们建议，与全脑分析相比，对卒中后隔离和专用子网的监视可能揭示了卒中恢复的详细方面。总之，我们的研究结果揭示了皮层下皮质相互作用对神经重组的贡献，并突出了中风康复的新途径。提出了在恢复过程中左右海马在功能上可分离的假设。此外，我们建议，与全脑分析相反，对卒中后隔离和专用子网的监视可能揭示了卒中恢复的详细方面。总之，我们的结果揭示了皮层下皮质相互作用对神经重组的贡献，并突出了中风康复的新途径。提出了在恢复过程中左右海马在功能上可分离的假设。此外，我们建议，与全脑分析相比，对卒中后隔离和专用子网的监视可能揭示了卒中恢复的详细方面。总之，我们的研究结果揭示了皮层下皮质相互作用对神经重组的贡献，并突出了中风康复的新途径。