Circadian clocks are endogenous coordinators of 24-hour rhythm of behavioral and molecular processes in living organism. They are composed of set of genes, which function as activators - CLOCK and BMAL1, which through binding to regulatory elements containing E-boxes activate transcription of repressor proteins Period (PER1) and cryptochrome (CRY1). The aim of the study was to assess: CLOCK, BMAL1, PER1 and CRY1 in obstructive sleep apnea (OSA) patients.

中文翻译：

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0059阻塞性睡眠呼吸暂停患者昼夜节律蛋白的破坏

昼夜节律是生物体内行为和分子过程的24小时节律的内源协调者。它们由一组基因组成，这些基因起激活剂的作用-CLOCK和BMAL1，它们通过与包含E-boxs的调节元件结合而激活阻遏蛋白Period（PER1）和隐色蛋白（CRY1）的转录。该研究的目的是评估阻塞性睡眠呼吸暂停（OSA）患者的CLOCK，BMAL1，PER1和CRY1。