Abstract

Introduction

A BMI increase, in men and women, is associated with an increased severity and progression of OSA. This study will examine the impact of BMI on varying levels of OSA severity and progression.

Methods

Participants, divided by sex, included 2728 (47%) men and 3076 (53%) women over the age of 40 that were in the Sleep Heart Health Study (SHHS). Participants were separated into 1 of 10 groups based on initial OSA levels at SHHS time point 1 (SHHS1) and ending OSA levels at SHHS time point 2 (SHHS2) as measured by RDI. A Kruskall-Wallis test examined the BMI median differences in the groups. Post-hoc tests, including pairwise comparisons and Wilcoxon rank sum test with Holm adjustment, were conducted to further examine results.

Results

Significant differences existed between certain groups (Men: Chi-Square=146.87, p<.001, df=9; Women: Chi-Square=128.59, p<.001, df=9). For men and women, those in the group with normal OSA levels at SHHS1 and SHHS2 had significant BMI differences compared to those in all 9 other groups where mild, moderate, or severe OSA levels exist at SHHS1 or SHHS2. Additionally, in men, BMI is significantly different for those with normal or mild OSA levels at SHHS2 compared to those with moderate or severe OSA levels at SHHS2. Also, a significant BMI difference exists in men maintaining mild OSA levels throughout SHHS compared to those maintaining severe OSA levels.

Conclusion

Although BMI is a known influential factor in OSA progression, this study demonstrated that those maintaining normal OSA levels over time have a significant BMI difference compared to those reaching even mild OSA levels over time. Additional implications were also found for men. These findings may coincide with recent research suggesting that one needs to progress only to moderate OSA levels to reach a tipping point of significantly increasing and impacting many health risks.

Support

Robert Wood Johnson Foundation Future of Nursing Scholars Program

中文翻译：

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0591体重指数在男女睡眠呼吸暂停水平变化中的意义

摘要

介绍

男性和女性的BMI升高与OSA的严重程度和进展增加相关。这项研究将检查BMI对OSA严重性和进展程度不同的影响。

方法

参加睡眠心脏健康研究（SHHS）的参与者（按性别划分）包括40岁以上的2728名男性（47％）和3076名女性（53％）。根据RDI测量，根据SHHS时间点1的初始OSA水平和SHHS时间点2的结束OSA水平（SHHS2），将参与者分为10组中的1组。Kruskall-Wallis检验检查了各组的BMI中位数差异。进行事后检验，包括成对比较和具有Holm调整的Wilcoxon秩和检验，以进一步检查结果。

结果

某些组之间存在显着差异（男性：卡方= 146.87，p <.001，df = 9；女性：卡方-128.59，p <.001，df = 9）。对于男性和女性，与SHHS1或SHHS2上存在轻度，中度或重度OSA的所有其他9个组相比，SHHS1和SHHS2的OSA水平正常的组的BMI差异显着。此外，在男性中，SHHS2中OSA水平正常或轻​​度的人的BMI与SHHS2中OSA水平中度或重度的人的BMI显着不同。此外，与维持严重OSA水平的男性相比，在整个SHHS中保持轻度OSA水平的男性存在显着的BMI差异。

结论

尽管BMI是OSA进展的已知影响因素，但这项研究表明，与随时间推移达到甚至轻度OSA水平的人相比，随着时间推移保持正常OSA水平的人BMI差异显着。还发现了对男性的其他影响。这些发现可能与最近的研究相吻合，后者表明人们仅需发展到中等OSA水平即可达到显着增加并影响许多健康风险的临界点。

支持

罗伯特·伍德·约翰逊基金会（Robert Wood Johnson Foundation）护理学者未来计划