Epigenetic markers such as DNA methylation of the monoamine oxidase A (MAOA) gene have previously been shown to be altered in anxiety- and stress-related disorders and to constitute a potential mechanism of action of psychotherapeutic interventions such as cognitive behavioral therapy in these disorders. The present study for the first time, to our knowledge, investigated MAOA methylation in patients with obsessive-compulsive disorder applying a longitudinal psychotherapy-epigenetic approach.

中文翻译：

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强迫症中的单胺氧化酶 A 低甲基化：成功心理治疗的可逆性？

先前已证明单胺氧化酶 A ( MAOA ) 基因的DNA 甲基化等表观遗传标记在焦虑和压力相关疾病中发生改变，并构成心理治疗干预（如这些疾病的认知行为疗法）的潜在作用机制。据我们所知，本研究首次采用纵向心理治疗表观遗传方法研究了强迫症患者的MAOA甲基化。