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Prop-2-ynyloxybenzyloxy substituted phthalocyanine-based polymeric nanoparticles: synthesis, photophysical properties and in vitro PDT efficacy
Journal of Coordination Chemistry ( IF 2.2 ) Pub Date : 2020-04-17 , DOI: 10.1080/00958972.2020.1766683
Shuanghuang Xiao 1 , Xiuqin Chen 1 , Qiuhao Ye 1 , Kuizhi Chen 1 , Wenling Xiao 1 , Xinqiao Guan 1 , Bingcheng Huang 1 , Guowei Liu 1 , Hui Wei 2 , Yiru Peng 1
Affiliation  

Abstract Two prop-2-ynyloxybenzyloxy axially/peripherally substituted zinc/silicon phthalocyanines (YSiPc and YZnPc) were synthesized. They were encapsulated into an amphiphilic block copolymeric micelle polyethylene glycol monomethyl ether-polycaprolactone (MPEG5000–PCL2000) to form polymeric nanoparticles YSiPc@MPEG5000–PCL2000 and YZnPc@MPEG5000–PCL2000. The photophysical and photochemical properties of these polymeric nanoparticles were studied by UV/Vis and fluorescence spectroscopy. The cellular uptake and reactive oxygen species (ROS) production abilities of two polymeric nanoparticles in MCF-7 breast cancer cells were evaluated by confocal laser scanning imaging. YSiPc@MPEG5000–PCL2000 exhibited a higher cellular uptake, higher ROS generation ability as well as higher photodynamic efficacy against MCF-7 cells. YSiPc@MPEG5000–PCL2000 is a promising photosensitizer for photodynamic therapy. Graphical Abstract

中文翻译:

Prop-2-ynyloxybenzyloxy 取代的酞菁基聚合物纳米粒子:合成、光物理特性和体外 PDT 功效

摘要 合成了两种丙-2-炔氧基苄氧基轴向/外围取代的锌/硅酞菁(YSiPc 和YZnPc)。它们被封装在两亲性嵌段共聚物胶束聚乙二醇单甲醚-聚己内酯(MPEG5000-PCL2000)中,形成聚合物纳米颗粒 YSiPc@MPEG5000-PCL2000 和 YZnPc@MPEG5000-PCL2000。通过紫外/可见光和荧光光谱研究了这些聚合物纳米粒子的光物理和光化学性质。通过共聚焦激光扫描成像评估了两种聚合物纳米粒子在 MCF-7 乳腺癌细胞中的细胞摄取和活性氧 (ROS) 产生能力。YSiPc@MPEG5000–PCL2000 表现出更高的细胞摄取、更高的 ROS 生成能力以及对 MCF-7 细胞的更高光动力功效。YSiPc@MPEG5000–PCL2000 是一种很有前途的光动力疗法光敏剂。图形概要
更新日期:2020-04-17
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