Internal organs of discarded scallops are rich in omega-3 polyunsaturated fatty acids, but it is not used as a food ingredient due to the presence of toxic substances. Recently, our research team prepared high-quality scallop oil (SCO) from the internal organs of the Japanese giant scallop (Patinopecten yessoensis), in which cadmium and diarrhetic shellfish toxin are below regulated levels. In this study, SCO was prepared from the internal organs of scallops obtained from Mutsu and Uchiura bays in Japan, and was referred to as SCO-M (scallop oil from Mutsu bay) and SCO-U (scallop oil from Uchiura bay), respectively. Acute and subacute toxicity studies were performed to assess the safety of the prepared SCO. In acute toxicity study, mice were orally administered SCO-M and SCO-U at a single dose of 5,000 mg/kg body weight. In a 28-day repeated oral dose toxicity study, the mice were fed diets containing 1% and 5% SCO-M and SCO-U; and in a 13-week repeated oral dose toxicity study, the mice were fed 5% SCO-M and SCO-U. There were no toxicologically significant changes in clinical signs, hematology, blood chemistry, and organ weights at any dose during the experiment. Therefore, it was concluded that SCO-M and SCO-U are safe for use as food ingredients under the experimental conditions of this study.

中文翻译：

---

从日本扇贝（Patinopecten yessoensis）的内脏中制备的小鼠油脂的单次和重复剂量28天和13周毒性研究。

废弃扇贝的内部器官富含 omega-3多不饱和脂肪酸，但由于存在有毒物质，因此不能用作食品成分。最近，我们的研究小组从日本巨型扇贝（Patinopecten yessoensis）的内脏中制备了高质量的扇贝油（SCO）。），其中的镉和腹泻性贝类毒素均低于规定水平。在这项研究中，SCO是从日本陆陆湾和内浦湾的扇贝内部器官制备的，分别称为SCO-M（陆陆湾的扇贝油）和SCO-U（内陆湾的扇贝油）。 。进行了急性和亚急性毒性研究，以评估所制备SCO的安全性。在急性毒性研究中，以5,000 mg / kg体重的单剂量口服给予SCO-M和SCO-U。在为期28天的重复口服剂量毒性研究中，给小鼠喂食了含1％和5％SCO-M和SCO-U的饮食；在一项为期13周的重复口服毒性研究中，给小鼠喂食了5％的SCO-M和SCO-U。临床体征，血液学，血液化学，实验期间任何剂量的器官重量和器官重量。因此，可以得出结论，在本研究的实验条件下，SCO-M和SCO-U可以安全地用作食品成分。