Comparative metabolism of gelsenicine in liver microsomes from humans, pigs, goats and rats.,Rapid Communications in Mass Spectrometry

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Comparative metabolism of gelsenicine in liver microsomes from humans, pigs, goats and rats.
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-05-26 , DOI: 10.1002/rcm.8843
Zi-Yuan Wang _{1,

2} , Ming-Ting Zuo _{1,

2} , Xue-Jiao Zhao _{1,

2} , Yu-Juan Li _{1,

2} , Zhi-Liang Sun _{1,

2} , Zhao-Ying Liu _{1,

2}

Affiliation

Gelsemium elegans (G. elegans ) is highly toxic to humans and rats but has insecticidal and growth‐promoting effects on pigs and goats. However, the mechanisms behind the toxicity differences of G. elegans are unclear. Gelsenicine, isolated from G. elegans , has been reported to be a toxic alkaloid.

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