The development of a safe, effective and affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. Hepatitis B‐C subviral envelope particles, which could be produced by industrial procedures adapted from those established for the hepatitis B virus vaccine, appear promising for use for this purpose. The prototype HBV‐HCV bivalent vaccine‐bearing genotype 1a HCV envelopes can induce neutralizing antibodies against this genotype, but is less effective against other genotypes. We show here, in a small animal model, that the use of a set of vaccine particles harbouring envelopes from different HCV genotypes in various association strategies can induce broad neutralizing protection or an optimized protection against a particular genotype prevalent in a given region, such as genotype 4 in Egypt. This vaccine could help to control the hepatitis C epidemic worldwide.

中文翻译：

---

混合来自各种HCV基因型的颗粒可提高HBV-HCV疫苗引发广泛交叉中和抗体的能力。

针对丙型肝炎病毒（HCV）的安全，有效和负担得起的预防性疫苗的开发仍然是医学上的优先事项。乙肝丙型肝炎病毒亚膜包膜颗粒可以通过工业方法生产而来，该方法可采用针对乙肝病毒疫苗建立的工业程序生产，似乎有望用于此目的。具有原型HBV-HCV二价疫苗的基因型1a HCV包膜可以诱导针对该基因型的中和抗体，但对其他基因型的效果较差。我们在一个小动物模型中显示，在各种关联策略中使用带有不同HCV基因型包膜的一组疫苗颗粒可以诱导广泛的中和保护或针对特定区域（例如特定区域）普遍存在的特定基因型的优化保护。埃及的基因型4。