Effect of Rooibos (Aspalathus linearis) extract on atorvastatin-induced toxicity in C3A liver cells.,Journal of Cellular Physiology

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Effect of Rooibos (Aspalathus linearis) extract on atorvastatin-induced toxicity in C3A liver cells.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-27 , DOI: 10.1002/jcp.29756
Danielle A Millar ₁ , Sandra Bowles ₁ , Shantal Lynn Windvogel _{2,

3} , Johan Louw ₁ , Christo J F Muller _{1,

3,

4}

Affiliation

Rooibos (Aspalathus linearis) has various health benefits. Two case studies have associated chronic Rooibos consumption with conventional prescription medications, including atorvastatin (ATV), with hepatotoxicity. Statins act by inhibiting hydroxymethylglutaryl‐coenzyme A reductase, a rate‐limiting enzyme in cholesterol synthesis. Although rare, statins are potentially hepatotoxic. The aim was to investigate interactions between aspalathin‐rich Rooibos extract GRT™ and ATV‐induced hepatotoxicity in C3A liver cells cultured with and without palmitate. Effects of co‐treatment of GRT + ATV on cell viability, oxidative stress, apoptosis, mitochondrial integrity, and cellular reactive oxygen species (ROS) production were assessed. Significantly increased ROS production was observed in cells exposed to ATV and palmitate. Combination therapy of GRT + ATV also showed significant increases in ROS production. Under palmitate‐treated conditions, ATV‐induced significant apoptosis which was not ameliorated by GRT + ATV co‐treatment. Despite studies purporting hepatoprotection from Rooibos, our study showed that GRT was unable to modulate ATV‐induced hepatotoxic effects in this model.

中文翻译：

Rooibos（Aspalathus linearis）提取物对阿托伐他汀诱导的C3A肝细胞毒性的影响。

如意宝（Asoiathus linearis）具有多种健康益处。两项案例研究将长期服用路易波宝与常规处方药（包括阿托伐他汀（ATV））与肝毒性相关联。他汀类药物通过抑制羟甲基戊二酰辅酶A还原酶（一种胆固醇合成中的限速酶）起作用。他汀类药物虽然很少见，但可能具有肝毒性。目的是研究富含和不加入棕榈酸酯的C3A肝细胞中富含天冬酰胺的Rooibos提取物GRT™与ATV诱导的肝毒性之间的相互作用。评估了GRT + ATV的共处理对细胞活力，氧化应激，细胞凋亡，线粒体完整性和细胞活性氧（ROS）产生的影响。在暴露于ATV和棕榈酸酯的细胞中观察到ROS的显着增加。GRT + ATV的联合治疗也显示ROS产生显着增加。在棕榈酸酯处理的条件下，ATV诱导了显着的细胞凋亡，而GRT + ATV的联合治疗并不能改善其凋亡。尽管有研究声称对Rooibos具有保肝作用，但我们的研究表明GRT在该模型中无法调节ATV诱导的肝毒性作用。

更新日期：2020-05-27

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