In recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting‐edge technology, including minimally invasive and organ‐preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bleeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for effective HAs adapted for LPN surgical peculiarities, which resulted on the emergence of different types of topical HAs. The most promising are the natural origin HAs because of their inherent biodegradability, biocompatibility, and lowest toxicity. These properties turn them top interests' candidates as HAs in LPN. In this review, we present a deep overview on the progress achieved in the design of HAs based on natural origin polymers, highlighting their distinguishable characteristics and providing a clear understanding of their hemostat's role in LPN. This way it may be possible to establish a structure–composition properties relation, so that novel HAs for LPN can be designed to explore current unmet medical needs.

中文翻译：

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在腹腔镜肾部分切除术中使用止血剂治疗手术出血：生物材料的观点。

近年来，肾脏肿瘤的发病率急剧上升，这促使尖端技术出现，包括微创和器官保留方法，如腹腔镜肾部分切除术（LPN）。LPN 是一种用于治疗小肾肿块的创新技术，由于其预期结果，在过去几十年中越来越受欢迎。然而，出血控制仍然是主要挑战，因为目前用于其他外科专业的大多数止血剂 (HA) 在 LPN 中效率低下。这加快了寻找适合 LPN 手术特性的有效 HA，从而导致出现了不同类型的局部 HA。最有前途的是天然来源的 HA，因为它们具有固有的生物降解性、生物相容性、和最低的毒性。这些属性使他们成为 LPN 中最感兴趣的候选人。在这篇综述中，我们对基于天然聚合物的 HA 设计取得的进展进行了深入概述，突出了它们的可区分特征，并清楚地了解了它们的止血剂在 LPN 中的作用。通过这种方式，可以建立结构-组成特性关系，从而可以设计用于 LPN 的新型 HA 来探索当前未满足的医疗需求。