Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS‐CoV‐2, natural killer cells and T cells become exhausted and decreasing their count leads to lymphopenia. Inability to eradicate the infected organ makes hyperinitiation of the immune system, which releases the excessive inflammatory cytokines to compensate the exhausted one as well as the low lymphocytes counts; it consequently leads to the cytokine storm syndrome. These mechanisms and the potential therapeutic targeting are discussed in this paper.

中文翻译：

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COVID-19中的淋巴细胞减少：治疗机会。

严重的急性呼吸综合症冠状病毒2（SARS-CoV-2）在世界范围内不受控制地传播。宿主的免疫反应强烈地试图使其面对所有潜在的细胞和细胞因子。患有SARS-CoV-2的慢性疾病后，自然杀伤细胞和T细胞就会精疲力尽，其数量减少会导致淋巴细胞减少。无法根除被感染的器官会使免疫系统过度启动，从而释放出过多的炎性细胞因子，以补偿疲惫的人以及淋巴细胞数量少的人。因此导致细胞因子风暴综合征。这些机制和潜在的治疗靶点在本文中进行了讨论。