Owing to extremely high salinity and harsh environmental conditions, T. articulata is one of the most abundant wild plants growing in the deserts of Saudi Arabia. Such plants may contain novel compounds to display promising biological activities. Here, in this study, we evaluate the biological activities of methanolic extracts of fresh leaves, dry leaves, stem, and roots of T. articulata. The antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and total phenolic and flavonoid content were determined using standard colorimetric methods. Whereas antimicrobial and ant-proliferative activities were determined by standard well-diffusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods, respectively. Our results demonstrate that all methanolic extracts of T. articulata showed antioxidant activity, however, the methanolic extract of dry leaves exhibits promising antioxidant effect with IC₅₀ value 49.08 ± 1.98, which was strongly supported by total phenolic (409.92 ± 6.03 mg GAE/g DW) and flavonoid (177.71 mg QE/g DW) content. Although, antimicrobial activity was also exhibited by all the methanolic extracts, however, methanolic extract of dry leaves exhibits promising antimicrobial activity in Gram-positive bacteria Staphylococcus epidemidis. Furthermore, MTT assay revealed that all methanolic extracts exhibit antiproliferative activity in MCF-7 (breast cancer) and RKO (colorectal cancer) cells with IC₅₀ values ranges from 219 ± 5.112 µg/ml to 253 ± 5.231 µg/ml and 220 ± 4.330 µg/ml to 325 ± 6.213 µg/ml, respectively. However, the most promising antiproliferative effect was displayed by methanolic extract of dry leaves with IC₅₀ values 219 ± 5.112 µg/ml and 220 ± 4.330 µg/ml, respectively. In summary, these findings provide evidence that T. articulata has promising biological activities and can be used for many pharmaceutical activities in the future.

由于极高的含盐量和恶劣的环境条件，T. articulata是最丰富的野生植物在沙特阿拉伯的沙漠里成长的一个。这样的植物可能包含新颖的化合物以展示有前途的生物活性。在这里，在这项研究中，我们评估新鲜的叶，干叶，茎和根的甲醇提取物的生物活性。抗氧化剂活性由2，2-二苯基-1-吡啶并肼基（DPPH）测定，总酚和类黄酮含量用标准比色法测定。而抗菌和抗增殖活性分别通过标准的良好扩散法和3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）方法确定。我们的结果表明，所有的T. articulata甲醇提取物表现出抗氧化活性，但是干叶的甲醇提取物显示出令人振奋的抗氧化作用，IC₅₀值为49.08±1.98，总酚（409.92±6.03 mg GAE / g DW）和类黄酮（177.71 mg QE / g DW）有力支持内容。虽然，所有的甲醇提取物也都具有抗菌活性，但是，干叶的甲醇提取物在革兰氏阳性细菌流行葡萄球菌中显示出有希望的抗菌活性。此外，MTT分析表明，所有甲醇提取物在MCF-7（乳腺癌）和RKO（结肠直肠癌）细胞中均表现出抗增殖活性，IC₅₀值范围为219±5.112 µg / ml至253±5.231 µg / ml和220±4.330 µg / ml分别达到325±6.213 µg / ml。然而，最有希望的抗增殖作用是由干叶的甲醇提取物表现出来的，IC₅₀值分别为219±5.112 µg / ml和220±4.330 µg / ml 。综上所述，这些发现提供了证据，证明T. articulata具有有前途的生物学活性，并且将来可用于许多药物活性。