Purpose

To identify the local spatiotemporal consistency of spontaneous brain activity of attention-deficit/hyperactivity disorder (ADHD) adolescents and its relation with clinical performance.

Materials and Methods

A cohort of 50 adolescents with ADHD-I or ADHD-C and a cohort of age- and gender- matched 46 typical development controls (TDC) were recruited from ADHD-200 dataset. FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) metric was used to analyze the local spatiotemporal consistency, which integrating local temporal homogeneity and regional stability of brain activity states. The difference of normalized FOCA (nFOCA) values among ADHD-Inattentive (ADHD-I), ADHD-Combined (ADHD-C) and TDC were detected using ANOVA and post-hoc analysis. Furthermore, partial correlations were analyzed to investigate the relationship between nFOCA values and clinical manifestations.

Results

Compared with TDC, ADHD-C and ADHD-I adolescents demonstrated alterations of FOCA in bilateral middle temporal gyrus, superior occipital gyrus, postcentral gyrus, precuneus, and right inferior temporal gyrus, lingual gyrus, superior frontal gyrus, left middle cingulum gyrus, middle occipital gyrus and cerebellum area.

Conclusions

Our study suggests that the FOCA method perhaps has potential to provide important insights into understanding the pathophysiological mechanism of ADHD and its subtypes.

中文翻译：

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注意缺陷/多动障碍儿童的时空一致性分析。

目的

目的确定注意力缺陷/多动障碍（ADHD）青少年自发性大脑活动的局部时空一致性及其与临床表现的关系。

材料和方法

从ADHD-200数据集中招募了50名患有ADHD-1或ADHD-C的青少年以及年龄和性别相匹配的46个典型发育对照（TDC）。局部神经活动的FOur维（时空）一致性（FOCA）指标用于分析局部时空一致性，整合了局部时间同质性和大脑活动状态的区域稳定性。使用ANOVA和事后分析检测ADHD注意力不集中（ADHD-1），ADHD合并（ADHD-C）和TDC之间的标准化FOCA（nFOCA）值的差异。此外，分析了部分相关性以调查nFOCA值与临床表现之间的关系。

结果

与TDC相比，ADHD-C和ADHD-I青少年表现出双侧中颞回，枕后上颌，中央后回，前颞神经和右下颞回，舌状回，额额上回，左中扣带回，中中间的FOCA改变。枕回和小脑区。

结论

我们的研究表明，FOCA方法可能有潜力为了解ADHD及其亚型的病理生理机制提供重要的见识。