Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window exhibits enhanced deep-tissue imaging capability. Likely, cancer therapy in the NIR-II window could provide deeper penetration depth and higher exposure to laser over NIR-I. However, the traditional application of excitation light is still in the NIR-I window. In view of the excellent imaging and therapeutic capabilities of NIR-II window, we have demonstrated a simple polyoxometalate (POM) clusters (molecular formula: (Na)_n(PMo₁₂O₄₀) or (NH₄⁺)_n(PMo₁₂O₄₀)), which integrates NIR-II photoacoustic imaging and NIR-II photothermal therapy into an “all-in-one” theranostic nanoplatform, and could be used for PA imaging-guided photothermal therapy in the NIR-II window. In vivo experiments demonstrate that the POM clusters with good water solubility and biocompatibility were effective to kill tumor without recurrence and metastasis under 1064 nm laser illumination.

在第二个近红外（NIR-II）窗口中的光声（PA）成像具有增强的深组织成像能力。与NIR-I相比，NIR-II窗口中的癌症治疗可能会提供更深的穿透深度和更高的激光照射率。但是，激发光的传统应用仍在NIR-1窗口中。鉴于NIR-II窗口的出色成像和治疗能力，我们证明了一个简单的多金属氧酸盐（POM）簇（分子式：（Na）_n（PMo ₁₂ O ₄₀）或（NH ₄ ⁺）_n（PMo ₁₂ O ₄₀）），将NIR-II光声成像和NIR-II光热疗法整合到一个“多合一”的治疗神经纳米平台中，并且可以在NIR-II窗口中用于PA成像引导的光热疗法。体内实验表明，在1064 nm激光照射下，具有良好水溶性和生物相容性的POM簇可有效杀死肿瘤而无复发和转移。