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Synthesis and Antifungal Activities of Hydrophilic Cationic Polymers against Rhizoctonia solani
Fungal Biology ( IF 2.9 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.funbio.2020.04.007 Weiqiang Zhong 1 , Yaoyao Chang 2 , Yaling Lin 2 , Anqiang Zhang 1
Fungal Biology ( IF 2.9 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.funbio.2020.04.007 Weiqiang Zhong 1 , Yaoyao Chang 2 , Yaling Lin 2 , Anqiang Zhang 1
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A series of linear hydrophilic cationic polymers with different charge density and molecular weights were synthesized by one-step polymerization process. The effect of the hydrophobicity and molecular weights on the antifungal activity against Rhizoctonia solani (R. solani) and Fusarium oxysporum f. sp. cubense race 4 (Foc4) was assessed. The biotoxicity of the cationic polymers were evaluated based on their median lethal concentration (LC50) for zebrafish and silkworm and median lethal dose (LD50) for Kunming mice. The results indicated that the balance between antifungal activity and biotoxicity could be well tuned by controlling the hydrophobic-hydrophilic balance. The minimum inhibitory concentration (MIC) of PEPB10 and PEPB25 against R. solani were 160 μg/mL and 80 μg/mL, respectively. And the LD50 for Kunming mice of PEPB10 and PEPB25 were more than 5000 mg/kg, which mean that PEPB10 and PEPB25 with high hydrophilicity show low toxicity and better selectivity for R. solani. The cationic polymers can kill the R. solani by damaging their membranes and exchanging the Ca2+ or/and Mg2+ cations of their membranes or cell wall. These results help to understand the antifungal mechanism of low-toxic polymeric quaternary ammonium salts and highlight their potential application as highly selective fungicidal agents for controlling plant diseases.
中文翻译：
亲水性阳离子聚合物抗立枯丝核菌的合成及抗真菌活性
通过一步聚合法合成了一系列具有不同电荷密度和分子量的线性亲水阳离子聚合物。疏水性和分子量对抗立枯丝核菌 (R. solani) 和尖孢镰刀菌 (Fusarium oxysporum f.) 抗真菌活性的影响。sp. 对立方体种族 4 (Foc4) 进行了评估。阳离子聚合物的生物毒性根据它们对斑马鱼和家蚕的中位致死浓度 (LC50) 和昆明小鼠的中位致死剂量 (LD50) 进行评估。结果表明，通过控制疏水-亲水平衡可以很好地调节抗真菌活性和生物毒性之间的平衡。PEPB10 和 PEPB25 对 R. solani 的最小抑制浓度 (MIC) 分别为 160 μg/mL 和 80 μg/mL。并且PEPB10和PEPB25对昆明小鼠的LD50均超过5000 mg/kg，说明亲水性高的PEPB10和PEPB25对R. solani表现出较低的毒性和更好的选择性。阳离子聚合物可以通过破坏 R. solani 的膜并交换其膜或细胞壁的 Ca2+ 或/和 Mg2+ 阳离子来杀死 R. solani。这些结果有助于了解低毒聚合季铵盐的抗真菌机制，并突出其作为高选择性杀菌剂防治植物病害的潜在应用。
更新日期：2020-08-01
中文翻译：
亲水性阳离子聚合物抗立枯丝核菌的合成及抗真菌活性
通过一步聚合法合成了一系列具有不同电荷密度和分子量的线性亲水阳离子聚合物。疏水性和分子量对抗立枯丝核菌 (R. solani) 和尖孢镰刀菌 (Fusarium oxysporum f.) 抗真菌活性的影响。sp. 对立方体种族 4 (Foc4) 进行了评估。阳离子聚合物的生物毒性根据它们对斑马鱼和家蚕的中位致死浓度 (LC50) 和昆明小鼠的中位致死剂量 (LD50) 进行评估。结果表明，通过控制疏水-亲水平衡可以很好地调节抗真菌活性和生物毒性之间的平衡。PEPB10 和 PEPB25 对 R. solani 的最小抑制浓度 (MIC) 分别为 160 μg/mL 和 80 μg/mL。并且PEPB10和PEPB25对昆明小鼠的LD50均超过5000 mg/kg，说明亲水性高的PEPB10和PEPB25对R. solani表现出较低的毒性和更好的选择性。阳离子聚合物可以通过破坏 R. solani 的膜并交换其膜或细胞壁的 Ca2+ 或/和 Mg2+ 阳离子来杀死 R. solani。这些结果有助于了解低毒聚合季铵盐的抗真菌机制，并突出其作为高选择性杀菌剂防治植物病害的潜在应用。
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