Background

Neuromuscular disorders e.g. spinal muscular atrophy and stroke have a negative impact on functional movement capability. These disorders affect lower and upper motor neurons respectively.

Methods

In this study high spatial resolution electromyography was used to record the motor unit activity in 3 groups: healthy subjects, a spinal muscular atrophy group and a stroke group. 7 clinically sensitive parameters were used to analyze the activation patterns of a few motor units.

Findings

In the case of spinal muscular atrophy there was no effect on motor unit activation but on their number. Stroke was characterized by fewer active motor units and a significantly reduced firing rate with low variability.

Interpretation

The results suggest, that for stroke, information from the brain is modified thereby resulting in motor units firing at their natural frequency. Thus, high spatial resolution electromyography and the chosen parameters facilitate non-invasive, objective differentiation and analysis of the activation patterns of motor units in neuromuscular disorders.

中文翻译：

---

与运动神经元水平和中风和脊髓性肌萎缩中病变位置相关的运动单位激活的非侵入性评估。

背景

神经肌肉疾病，例如脊柱肌肉萎缩和中风对功能运动能力有负面影响。这些疾病分别影响下和上运动神经元。

方法

在这项研究中，高空间分辨率肌电图用于记录3组运动单位的活动：健康受试者，脊髓性肌萎缩组和中风组。使用7个临床敏感参数来分析几个运动单元的激活模式。

发现

在脊髓性肌萎缩的情况下，对运动单位的激活没有影响，但对其数量有影响。冲程的特征在于有效的电动机单元较少，点火速度显着降低，且变化性较低。

解释

结果表明，对于中风，来自大脑的信息被修改，从而导致运动单位以其自然频率点火。因此，高空间分辨率的肌电图和所选择的参数有助于非侵入性，客观的区分和神经肌肉疾病中运动单元激活模式的分析。