Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. The sentinel node was cut in half, parallel to the longest axis, to obtain the maximum section area. After performing imprint cytology, one half was used to create a frozen section. The specimen was cut at 2-mm intervals into 5-μm-thick sections, which were subjected to hematoxylin and eosin staining. The diagnostic accuracy of intraoperative frozen section analyses and imprint cytology was compared to the final pathological diagnosis. Among 951 detected sentinel nodes, 51 nodes were found to be positive in the final pathological diagnosis. The sensitivity of a frozen section analysis, imprint cytology and the combination of the two modalities was 76.5%, 72.6%, and 92.2%, respectively. The specificity of a frozen section analysis and imprint cytology was 100%. The negative predictive value of a frozen section analysis and imprint cytology was 98.7% and 98.5%, respectively. In these settings, the accuracy of the frozen section analysis and imprint cytology in the evaluation of SNB specimens was considered acceptable; however, the sensitivity of the combined approach was higher in comparison to when a frozen section analysis or imprint cytology was performed alone.

前哨淋巴结活检（SNB）可能是功能保留手术的决策工具，包括在宫颈癌和子宫内膜癌的治疗中进行根治性气管切除术和卵巢保留术。术中诊断对于指导这些情况的患者的治疗决策至关重要。371例宫颈癌和子宫内膜癌患者接受了SNB，并进行了术中冰冻切片分析和印迹细胞学检查。将前哨节点切成平行于最长轴的一半，以获得最大的截面面积。进行印迹细胞学检查后，将一半用于制作冷冻切片。将样品以2mm的间隔切成5μm厚的切片，然后进行苏木精和曙红染色。将术中冰冻切片分析和印迹细胞学的诊断准确性与最终病理学诊断进行比较。在951个前哨淋巴结中，有51个在最终病理诊断中呈阳性。冷冻切片分析，印迹细胞学检查和两种方式的组合的敏感性分别为76.5％，72.6％和92.2％。冷冻切片分析和印迹细胞学检查的特异性为100％。冷冻切片分析和印迹细胞学检查的阴性预测值分别为98.7％和98.5％。在这种情况下，冷冻切片分析和印迹细胞学在SNB标本评估中的准确性被认为是可以接受的。然而，